PVRIG
PVRIG，即CD112R，是一種免疫抑制性受體，主要表達(dá)在NK細(xì)胞和T細(xì)胞表面。它擁有獨(dú)特的結(jié)構(gòu)，包括跨膜區(qū)、細(xì)胞內(nèi)結(jié)構(gòu)域和細(xì)胞外免疫球蛋白可變樣結(jié)構(gòu)域，這使得它能夠識(shí)別和結(jié)合配體PVRL2，從而發(fā)揮免疫功能調(diào)節(jié)作用。當(dāng)PVRIG與PVRL2結(jié)合時(shí)，它會(huì)抑制免疫激活，并通過與CD226競爭結(jié)合配體來阻斷刺激信號(hào)的傳遞。在腫瘤環(huán)境中，腫瘤細(xì)胞通過高表達(dá)PVRL2與免疫細(xì)胞的PVRIG結(jié)合，傳遞抑制性信號(hào)，實(shí)現(xiàn)免疫逃逸。至于信號(hào)通路，PVRIG與配體的結(jié)合會(huì)觸發(fā)一系列細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)事件，導(dǎo)致免疫細(xì)胞功能受到抑制。因此，深入研究PVRIG的結(jié)構(gòu)、功能和信號(hào)通路對于理解免疫抑制機(jī)制以及開發(fā)新的免疫療法具有重要意義。
熱銷產(chǎn)品
Recombinant Human Transmembrane protein PVRIG (PVRIG)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PVRIG Antibodies
PVRIG for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA721905LA01HU | PVRIG Antibody | Human | ELISA, WB, IF |
| CSB-PA721905LB01HU | PVRIG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA721905LC01HU | PVRIG Antibody, FITC conjugated | Human | |
| CSB-PA721905LD01HU | PVRIG Antibody, Biotin conjugated | Human | ELISA |
PVRIG Proteins
PVRIG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP721905HU1 CSB-EP721905HU1 CSB-BP721905HU1 CSB-MP721905HU1 CSB-EP721905HU1-B |
Recombinant Human Transmembrane protein PVRIG (PVRIG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF721905HU | Recombinant Human Transmembrane protein PVRIG (PVRIG) | in vitro E.coli expression system |
| CSB-MP721905HU | Recombinant Human Transmembrane protein PVRIG (PVRIG)-VLPs | Mammalian cell |
