PVRIG Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PVRIG Polyclonal antibody
Uniprot No.：

Q6DKI7
基因名：

PVRIG
別名：

PVRIG; C7orf15; Transmembrane protein PVRIG; CD112 receptor; CD112R; Poliovirus receptor-related immunoglobulin domain-containing protein
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transmembrane protein PVRIG protein (193-326AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
基因功能參考文獻：
1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
組織特異性：

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
數據庫鏈接：

HGNC: 32190

OMIM: 617012

KEGG: hsa:79037

STRING: 9606.ENSP00000316675

UniGene: Hs.729356

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