PVR
PVR，全名為脊髓灰質(zhì)炎病毒受體，是一種跨膜糖蛋白，屬于nectin家族。它有多種別名，如CD155、HVED、PVS等。PVR蛋白在細(xì)胞粘附、信號傳導(dǎo)和免疫反應(yīng)中發(fā)揮重要作用。在脊髓灰質(zhì)炎病毒感染中，PVR作為病毒受體，介導(dǎo)病毒進入細(xì)胞。此外，PVR還與多種疾病相關(guān)，如腫瘤、自身免疫疾病等。目前，針對PVR的藥物研發(fā)主要集中在開發(fā)抗腫瘤藥物，如針對PVR的抗體藥物，以抑制腫瘤生長和轉(zhuǎn)移。
熱銷產(chǎn)品
Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) (CSB-MP019093HU(M))
驗證數(shù)據(jù)
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
PVR Recombinant Monoclonal Antibody (CSB-RA567944A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: Poliovirus Receptor antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
IHC image of CSB-RA567944A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.42% DAB.
PVR Antibodies
PVR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019093ESR1HU | PVR Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA019093ESR2HU | PVR Antibody | Human | ELISA, IHC |
| CSB-PA006288 | PVR Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA297000 | PVR Antibody | Human | ELISA,WB,IHC |
| CSB-RA567944A0HU | PVR Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
PVR Proteins
PVR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019093HU CSB-BP019093HU CSB-MP019093HU CSB-EP019093HU-B |
Recombinant Human Poliovirus receptor (PVR), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF019093HU(A4) | Recombinant Human Poliovirus receptor (PVR) | in vitro E.coli expression system |
| CSB-EP019093HU | Recombinant Human Poliovirus receptor (PVR), partial | E.coli |
| CSB-MP019093HU(M) | Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) | Mammalian cell |
| CSB-MP019093HU(A4) | Recombinant Human Poliovirus receptor (PVR)-VLPs | Mammalian cell |
| CSB-MP019093HUc7 | Recombinant Human Poliovirus receptor (PVR), partial | Mammalian cell |
PVR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP341328DSU CSB-EP341328DSU CSB-BP341328DSU CSB-MP341328DSU CSB-EP341328DSU-B |
Recombinant Chlorocebus aethiops Poliovirus receptor homolog (PVR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PVR ELISA Kit
PVR ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019093HU | Human Poliovirus receptor(PVR) ELISA kit | serum, plasma, tissue homogenates | 1.95 ng/mL |
