PTPRC
PTPRC，即蛋白酪氨酸磷酸酶受體C型，它是一種跨膜蛋白酪氨酸磷酸酶，廣泛表達于T淋巴細胞、B淋巴細胞、自然殺傷細胞（NK細胞）和巨噬細胞等免疫細胞中。PTPRC通過去磷酸化作用調節多種信號傳導途徑，包括但不限于細胞生長、分化、有絲分裂和致癌轉化等細胞過程。它參與調控的信號通路主要有T細胞受體(TCR)和B細胞受體(BCR)的信號傳導，通過與抗原受體復合物直接相互作用，或激活Src家族激酶，對抗原受體信號轉導進行調節。此外，PTPRC還抑制JAK激酶，作為細胞因子受體信號轉導的調節者。在生物學意義上，PTPRC對維持免疫系統的正常功能至關重要，其異常表達或功能失調與多種自身免疫疾病和癌癥的發生發展有關。
熱銷產品
Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial (CSB-EP019049HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PTPRC Recombinant Monoclonal Antibody (CSB-RA019049MA1HU)
驗證數據
Overlay Peak curve showing 293 cells surface stained with CSB-RA019049MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
PTPRC Antibodies
PTPRC for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA019049KA01HU | PTPRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA446974 | Phospho-PTPRC (Ser1007) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA040112 | Phospho-PTPRC (S1007) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA010546 | PTPRC Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA480713 | PTPRC Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA868166 | PTPRC Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA019049A0HU | CD45 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-MA019049A0m | CD45 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-RA019049MA1HU | PTPRC Recombinant Monoclonal Antibody | Human | ELISA, FC |
PTPRC for H
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA000202 | PTPRC Monoclonal Antibody | Human | ELISA,WB,IHC |
PTPRC Proteins
PTPRC Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial | Yeast |
| CSB-EP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial | E.coli |
| CSB-BP019049HU CSB-MP019049HU CSB-EP019049HU-B |
Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019049MO CSB-EP019049MO CSB-BP019049MO CSB-MP019049MO CSB-EP019049MO-B |
Recombinant Mouse Receptor-type tyrosine-protein phosphatase C (Ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019049RA CSB-EP019049RA CSB-BP019049RA CSB-MP019049RA CSB-EP019049RA-B |
Recombinant Rat Receptor-type tyrosine-protein phosphatase C (Ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Cyprinus carpio (Common carp)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP864275EQE CSB-EP864275EQE CSB-BP864275EQE CSB-MP864275EQE CSB-EP864275EQE-B |
Recombinant Cyprinus carpio Receptor-type tyrosine-protein phosphatase C (ptprc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
