PRPS2
PRPS2，全稱為磷酸核糖焦磷酸合成酶2，是一種參與核苷酸生物合成的關(guān)鍵酶。它催化磷酸核糖焦磷酸（PRPP）的合成，而PRPP是嘌呤和嘧啶核苷酸合成及組氨酸和色氨酸代謝的關(guān)鍵前體。PRPS2蛋白家族包括PRPS1、PRPS2和PRPS1L1等成員，它們具有高度保守的催化結(jié)構(gòu)域，但在組織表達(dá)和調(diào)控機(jī)制上存在差異。
PRPS2主要在增殖活躍的組織如骨髓、淋巴組織和某些腫瘤中高表達(dá)，其活性受ADP和GDP的變構(gòu)抑制以維持核苷酸代謝平衡。PRPS2突變可能導(dǎo)致酶活性異常，影響核苷酸合成，與某些遺傳性疾病如Arts綜合征（聽力損失、共濟(jì)失調(diào)和智力障礙）及癌癥發(fā)展相關(guān)。PRPS2過表達(dá)會(huì)促進(jìn)核苷酸合成，支持細(xì)胞快速增殖，常見于白血病、淋巴瘤等惡性腫瘤中，可能通過激活Ras/MAPK等通路加劇腫瘤進(jìn)展。該蛋白的表達(dá)受MYC、E2F等轉(zhuǎn)錄因子調(diào)控，在能量代謝重編程中起重要作用。
熱銷產(chǎn)品
PRPS2 Antibody (CSB-PA018779LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: PRPS2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 36 kDa
Observed band size: 35 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018779LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018779LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA018779LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PRPS2 Antibodies
PRPS2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018779LA01HU | PRPS2 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA018779LB01HU | PRPS2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018779LC01HU | PRPS2 Antibody, FITC conjugated | Human | |
| CSB-PA018779LD01HU | PRPS2 Antibody, Biotin conjugated | Human | ELISA |
PRPS2 Proteins
PRPS2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018779HU CSB-EP018779HU CSB-BP018779HU CSB-MP018779HU CSB-EP018779HU-B |
Recombinant Human Ribose-phosphate pyrophosphokinase 2 (PRPS2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
