PRIM2
PRIM2 is a protein in humans that is encoded by PRIM2 gene. Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Stabilizes and modulates the activity of the catalytic subunit (By similarity).
PRIM2 Antibodies
PRIM2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018681GA01HU | PRIM2 Antibody | Human,Mouse,Rat | ELISA,WB |
PRIM2 Proteins
PRIM2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018681MO CSB-EP018681MO CSB-BP018681MO CSB-MP018681MO CSB-EP018681MO-B |
Recombinant Mouse DNA primase large subunit (Prim2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRIM2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018681HU CSB-EP018681HU CSB-BP018681HU CSB-MP018681HU CSB-EP018681HU-B |
Recombinant Human DNA primase large subunit (PRIM2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRIM2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018681RA CSB-EP018681RA CSB-BP018681RA CSB-MP018681RA CSB-EP018681RA-B |
Recombinant Rat DNA primase large subunit (Prim2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRIM2 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP684852DKK CSB-EP684852DKK CSB-BP684852DKK CSB-MP684852DKK CSB-EP684852DKK-B |
Recombinant Dictyostelium discoideum DNA primase large subunit (prim2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
