PRIM1
PRIM1 is a protein in humans that is encoded by PRIM1 gene. Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Can add both ribo- and deoxynucleotides during elongation of the primers (By similarity). Binds single stranded DNA (By similarity).
PRIM1 Antibodies
PRIM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018680GA01HU | PRIM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA972371 | PRIM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003853 | PRIM1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA018680LA01HU | PRIM1 Antibody | Human | ELISA, IF |
| CSB-PA018680LB01HU | PRIM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018680LC01HU | PRIM1 Antibody, FITC conjugated | Human | |
| CSB-PA018680LD01HU | PRIM1 Antibody, Biotin conjugated | Human | ELISA |
PRIM1 Proteins
PRIM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018680MO CSB-EP018680MO CSB-BP018680MO CSB-MP018680MO CSB-EP018680MO-B |
Recombinant Mouse DNA primase small subunit (Prim1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRIM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018680HU CSB-BP018680HU CSB-MP018680HU CSB-EP018680HU-B |
Recombinant Human DNA primase small subunit (PRIM1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018680HU | Recombinant Human DNA primase small subunit (PRIM1) | E.coli |
