PPP2R1A
PPP2R1A，全稱為Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform，常見別名包括MRD36、PP2AA、PR65A、PP2AAALPHA、PP2A-Aalpha等。該蛋白是蛋白磷酸酶2A（PP2A）復合物的重要組成部分，負責連接催化亞基和調節亞基，從而形成具有不同底物特異性和功能的PP2A復合物。PPP2R1A在維持細胞穩態中起關鍵作用，其突變或表達異常與多種疾病相關，尤其是癌癥。例如，PPP2R1A的某些突變會導致PP2A功能喪失，進而促進細胞增殖和腫瘤發生，這些突變在子宮內膜癌、卵巢癌和肺癌中較為常見。PPP2R1A的過表達可能增強PP2A的抑癌功能，抑制腫瘤生長，而降低表達則可能導致PP2A活性下降，增加細胞異常增殖的風險。此外，PPP2R1A還參與調控Wnt、MAPK和PI3K/AKT等通路，影響細胞分化、遷移和存活。近年來，研究發現PPP2R1A突變與免疫治療敏感性相關，突變型腫瘤在免疫治療后能顯著延長患者生存期，這為癌癥治療提供了新的思路和靶點。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PPP2R1A Antibodies
PPP2R1A for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA018562GA01HU | PPP2R1A Antibody | Human,Mouse,Rat | ELISA,WB |
PPP2R1A Proteins
PPP2R1A Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018562HU CSB-EP018562HU CSB-BP018562HU CSB-MP018562HU CSB-EP018562HU-B |
Recombinant Human Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018562HUa0 | Recombinant Human Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) |
PPP2R1A Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018562PI CSB-EP018562PI CSB-BP018562PI CSB-MP018562PI CSB-EP018562PI-B |
Recombinant Pig Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPP2R1A Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP654194BO CSB-EP654194BO CSB-BP654194BO CSB-MP654194BO CSB-EP654194BO-B |
Recombinant Bovine Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PPP2R1A Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP758842MO CSB-EP758842MO CSB-BP758842MO CSB-MP758842MO CSB-EP758842MO-B |
Recombinant Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Ppp2r1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
