POLE
POLE，即DNA聚合酶ε，別名POLE1。POLE基因編碼的DNA聚合酶ε是DNA復(fù)制過(guò)程中的關(guān)鍵酶，它負(fù)責(zé)在DNA復(fù)制叉處添加新的核苷酸，并具有校對(duì)功能，以確保復(fù)制的準(zhǔn)確性。POLE的作用機(jī)制涉及其聚合酶活性和校正活性，其中校對(duì)功能通過(guò)其外切酶域?qū)崿F(xiàn)，能夠識(shí)別并切除錯(cuò)誤的核苷酸配對(duì)。POLE基因突變，尤其是外切酶域的突變，會(huì)導(dǎo)致DNA復(fù)制過(guò)程中的錯(cuò)誤不能被及時(shí)糾正，從而引起高突變負(fù)荷（hypermutagenesis），增加腫瘤發(fā)生的風(fēng)險(xiǎn)。POLE突變與多種腫瘤的發(fā)生發(fā)展有關(guān)，包括子宮內(nèi)膜癌、結(jié)直腸癌、非小細(xì)胞肺癌等。POLE突變型腫瘤因其高突變負(fù)荷和可能產(chǎn)生的新抗原而成為免疫治療的潛在候選者。POLE突變檢測(cè)在腫瘤的診斷、預(yù)后評(píng)估和治療選擇中具有重要意義。
熱銷(xiāo)產(chǎn)品
POLE Antibody (CSB-PA894382LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry analysis of human breast cancer using CSB-PA894382LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA894382LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
POLE Antibodies
POLE for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA824463 | POLE Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA030113 | POLE Antibody | Human,Rat | IHC, ELISA |
| CSB-PA894382LA01HU | POLE Antibody | Human | ELISA, IHC, IF |
| CSB-PA894382LB01HU | POLE Antibody, HRP conjugated | Human | ELISA |
| CSB-PA894382LC01HU | POLE Antibody, FITC conjugated | Human | |
| CSB-PA894382LD01HU | POLE Antibody, Biotin conjugated | Human | ELISA |
POLE Proteins
POLE Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP687703DKK CSB-EP687703DKK CSB-BP687703DKK CSB-MP687703DKK CSB-EP687703DKK-B |
Recombinant Dictyostelium discoideum DNA polymerase epsilon catalytic subunit A (pole), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POLE Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP894382MO CSB-EP894382MO CSB-BP894382MO CSB-MP894382MO CSB-EP894382MO-B |
Recombinant Mouse DNA polymerase epsilon catalytic subunit A (Pole), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
