PCBP2
PCBP2，即聚(rC)結(jié)合蛋白2，別名HNRPE2、HNRNPE2、hnRNP-E2。PCBP2是一種RNA結(jié)合蛋白，含有三個K同源（KH）結(jié)構(gòu)域，這些結(jié)構(gòu)域參與RNA結(jié)合。PCBP2涉及多種細(xì)胞途徑，包括mRNA穩(wěn)定性和翻譯控制。PCBP2與PCBP-1一起，通過與IRES的莖環(huán)IV的序列特異性相互作用，作為脊髓灰質(zhì)炎病毒RNA的翻譯共激活因子，促進(jìn)脊髓灰質(zhì)炎病毒RNA復(fù)制。PCBP2還參與15-脂氧合酶mRNA、人乳頭瘤病毒16型L2 mRNA和甲型肝炎病毒RNA的翻譯控制。PCBP2在多種生理過程中發(fā)揮作用，包括基因表達(dá)的轉(zhuǎn)錄和轉(zhuǎn)錄后調(diào)控，以及在病毒感染中的RNA復(fù)制和翻譯調(diào)控。PCBP2還與多種疾病相關(guān)，包括前顳葉癡呆和慢性髓系白血病。
熱銷產(chǎn)品
Recombinant Human Poly (rC)-binding protein 2 (PCBP2) (CSB-EP622995HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PCBP2 Antibody (CSB-PA622995LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate
All lanes: PCBP2 antibody at 5.3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 39, 35, 36, 34 kDa
Observed band size: 43 kDa
IHC image of CSB-PA622995LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA622995LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
PCBP2 Antibodies
PCBP2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017517GA01HU | PCBP2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA622995LA01HU | PCBP2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA622995LB01HU | PCBP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA622995LC01HU | PCBP2 Antibody, FITC conjugated | Human | |
| CSB-PA622995LD01HU | PCBP2 Antibody, Biotin conjugated | Human | ELISA |
PCBP2 Proteins
PCBP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP622995HU CSB-BP622995HU CSB-MP622995HU CSB-EP622995HU-B |
Recombinant Human Poly (rC)-binding protein 2 (PCBP2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP622995HU | Recombinant Human Poly (rC)-binding protein 2 (PCBP2) | E.coli |
