PARP1
PARP1（聚腺苷二磷酸核糖聚合酶1）是一種分子量為116 kDa的多功能酶，由三個(gè)主要結(jié)構(gòu)域組成：DNA結(jié)合域、自身修飾域和催化域。PARP1在細(xì)胞內(nèi)扮演著多種重要角色，包括DNA單鏈斷裂修復(fù)、基因轉(zhuǎn)錄調(diào)控和細(xì)胞死亡調(diào)控。當(dāng)DNA受損時(shí)，PARP1迅速被激活，通過形成PARP-DNA復(fù)合物來招募其他修復(fù)蛋白，參與堿基切除修復(fù)（BER）、非同源末端連接（NHEJ）和同源重組修復(fù)（HRR）等DNA修復(fù)途徑。此外，PARP1通過ADP核糖化改變?nèi)旧|(zhì)結(jié)構(gòu)和轉(zhuǎn)錄活性，與轉(zhuǎn)錄因子相互作用，調(diào)節(jié)基因表達(dá)。在嚴(yán)重DNA損傷情況下，PARP1的激活還會(huì)導(dǎo)致NAD+耗盡，引發(fā)細(xì)胞死亡。PARP1的活性受到諸如PTEN等抑癌基因的調(diào)控，并與ATM、BRCA1、BRCA2等蛋白相互作用，參與DNA損傷響應(yīng)和細(xì)胞周期調(diào)控。PARP1抑制劑的開發(fā)已成為治療特定類型癌癥的重要策略，特別是在卵巢癌和乳腺癌的治療中。
PARP1 Antibodies
PARP1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017457GA01HU | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA010134 | Cleaved-PARP1 (A214) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA000059 | Cleaved-PARP1 (G215) Antibody | Human | WB, ELISA |
| CSB-PA000080 | Cleaved-PARP1 (D214) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA966699 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA436053 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA405636 | PARP1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA890185 | Acetyl-PARP1 (K521) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA017457LA01HU | PARP1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA017457LB01HU | PARP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017457LC01HU | PARP1 Antibody, FITC conjugated | Human | |
| CSB-PA017457LD01HU | PARP1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA160472A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA581794A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-RA258431A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
PARP1 for H
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000290 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
| CSB-MA000291 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
| CSB-MA000305 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
PARP1 Proteins
PARP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457MO CSB-EP017457MO CSB-BP017457MO CSB-MP017457MO CSB-EP017457MO-B |
Recombinant Mouse Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457BO CSB-EP017457BO CSB-BP017457BO CSB-MP017457BO CSB-EP017457BO-B |
Recombinant Bovine Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457CH CSB-EP017457CH CSB-BP017457CH CSB-MP017457CH CSB-EP017457CH-B |
Recombinant Chicken Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457RA CSB-EP017457RA CSB-BP017457RA CSB-MP017457RA CSB-EP017457RA-B |
Recombinant Rat Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457HU CSB-EP017457HU CSB-BP017457HU CSB-MP017457HU CSB-EP017457HU-B |
Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017459HU | Recombinant human Poly [ADP-ribose] polymerase 11（PARP11), partial | E.coli |
| CSB-EP017457HU1 | Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | E.coli |
PARP1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017457XBE CSB-EP017457XBE CSB-BP017457XBE CSB-MP017457XBE CSB-EP017457XBE-B |
Recombinant Xenopus laevis Poly [ADP-ribose] polymerase 1 (parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Oryza sativa subsp. japonica (Rice)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP765912OFG CSB-EP765912OFG CSB-BP765912OFG CSB-MP765912OFG CSB-EP765912OFG-B |
Recombinant Oryza sativa subsp. japonica Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP874170DXU CSB-EP874170DXU CSB-BP874170DXU CSB-MP874170DXU CSB-EP874170DXU-B |
Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 ELISA Kit
PARP1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10705h | Human Poly ADP ribose polymerase,PARP ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
