OSM

OSM，全稱(chēng)為 Oncostatin M，是一種細(xì)胞因子，在調(diào)節(jié)炎癥和腫瘤等生理和病理功能中發(fā)揮重要作用。OSM蛋白主要由活化的巨噬細(xì)胞、腫瘤相關(guān)成纖維細(xì)胞、T細(xì)胞、樹(shù)突狀細(xì)胞和中性粒細(xì)胞等多種細(xì)胞合成和分泌。OSM蛋白通過(guò)與gp130細(xì)胞外細(xì)胞因子結(jié)合同源區(qū)結(jié)合，隨后招募LIFRβ形成I型受體復(fù)合物或OSMRβ形成II型受體復(fù)合物，激活多種信號(hào)通路，參與多種生理和病理功能，包括炎癥、腫瘤和肌肉萎縮等。OSM蛋白在肺部炎癥和腫瘤中發(fā)揮重要作用，例如在肺纖維化、哮喘和慢性阻塞性肺疾病中，OSM蛋白參與細(xì)胞外基質(zhì)蛋白沉積或分解代謝、細(xì)胞增殖和細(xì)胞存活等過(guò)程的調(diào)控。此外，OSM蛋白還與肺癌和惡病質(zhì)等疾病相關(guān)。目前，針對(duì)OSM蛋白通路藥物的臨床前研究取得了一定進(jìn)展，例如抗OSM抗體和納米抗體等，顯示出良好的治療效果，但尚無(wú)藥物獲批用于臨床疾病的治療。未來(lái)，OSM蛋白通路藥物有望成為治療肺部疾病和腫瘤等疾病的新選擇。

熱銷(xiāo)產(chǎn)品

Recombinant Human Oncostatin-M (OSM), partial (Active) (CSB-MP017260HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human OSM at 2μg/mL can bind Anti-OSM recombinant antibody (CSB-RA017260MA1HU)，the EC₅₀ is 3.048-3.860 ng/mL.

OSM Recombinant Monoclonal Antibody (CSB-RA017260MA1HU) captured on Protein A Chip can bind Recombinant Human OSM protein with an affinity constant of 0.59 nM as detected by MetaSPR Assay (WeSPRTM 200).

Recombinant Human Oncostatin-M (OSM) (Active) (CSB-MP017260HU-WD)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

OSM Recombinant Monoclonal Antibody (CSB-RA017260MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human OSM with Anti-OSM Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human OSM (CSB-MP017260HU1) at 2 μg/mL can bind Anti-OSM recombinant antibody, the EC₅₀ is 3.048-3.860 ng/mL.

OSM Antibody (CSB-PA09694A0Rb)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA09694A0Rb diluted at 1:90 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA09694A0Rb diluted at 1:90 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Oncostatin-M,OSM ELISA KIT (CSB-E04696h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E04696h

規(guī)格：96T/48T

靈敏度：1.56 pg/mL

檢測(cè)范圍：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

OSM Antibody

OSM Protein

OSM ELISA Kit

OSM Antibodies

OSM for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA09694A0Rb	OSM Antibody	Human	ELISA, IHC
CSB-PA09694C0Rb	OSM Antibody, FITC conjugated	Human
CSB-PA09694B0Rb	OSM Antibody, HRP conjugated	Human	ELISA
CSB-PA244255	OSM Antibody	Human	ELISA,WB,IHC
CSB-PA934414	OSM Antibody	Human	ELISA,IHC
CSB-RA017260MA1HU	OSM Recombinant Monoclonal Antibody	Human	ELISA

OSM for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA723970LA01RA	Osm Antibody	Rat	ELISA, IF
CSB-PA723970LB01RA	Osm Antibody, HRP conjugated	Rat	ELISA
CSB-PA723970LC01RA	Osm Antibody, FITC conjugated	Rat

OSM Proteins

OSM Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP017260HU CSB-EP017260HU CSB-BP017260HU CSB-MP017260HU CSB-EP017260HU-B	Recombinant Human Oncostatin-M (OSM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017260HU2	Recombinant Human Oncostatin-M (OSM), partial	E.coli
CSB-AP002231HU	Recombinant Human Oncostatin-M protein (OSM), partial (Active)	E.Coli
CSB-AP002241HU	Recombinant Human Oncostatin-M protein (OSM), partial (Active)	E.Coli
CSB-AP002251HU	Recombinant Human Oncostatin-M protein (OSM), partial (Active)	E.Coli
CSB-EP017260HU1	Recombinant Human Oncostatin-M (OSM)	E.coli
CSB-YP017260HUc7	Recombinant Human Oncostatin-M (OSM), partial	Yeast
CSB-MP017260HU1	Recombinant Human Oncostatin-M (OSM), partial (Active)	Mammalian cell
CSB-MP017260HU1d9	Recombinant Human Oncostatin-M (OSM), partial	Mammalian cell
CSB-MP017260HU-WD	Recombinant Human Oncostatin-M (OSM) (Active)	Mammalian cell

OSM Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP017260BO CSB-EP017260BO CSB-BP017260BO CSB-MP017260BO CSB-EP017260BO-B	Recombinant Bovine Oncostatin-M (OSM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

OSM Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-BP017260MO CSB-EP017260MO-B	Recombinant Mouse Oncostatin-M (Osm)	Baculovirus In Vivo Biotinylation in E.coli

OSM Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP723970RA	Recombinant Rat Oncostatin-M (Osm)	Yeast
CSB-EP723970RA CSB-BP723970RA CSB-EP723970RA-B	Recombinant Rat Oncostatin-M (Osm)	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP723970RA	Recombinant Rat Oncostatin-M (Osm)	Mammalian cell
CSB-EP723970RAb0	Recombinant Rat Oncostatin-M (Osm)	E.coli