OPRM1
OPRM1，即μ型阿片受體（mu opioid receptor），也稱為MOR。該受體是人體內源性阿片肽的主要靶點，參與疼痛感知、情緒調節和成癮等生理過程。μ型阿片受體屬于G蛋白偶聯受體超家族，具有7次跨膜結構，通過與內源性阿片肽或外源性阿片類藥物結合，激活下游信號通路，影響神經元的活動。
μ型阿片受體在多種生理和病理過程中發揮重要作用。例如，內源性阿片肽如β-內啡肽和腦啡肽與其結合后，可以產生鎮痛、欣快感等效應。μ型阿片受體也參與成癮的發生，長期使用阿片類藥物會導致μ型阿片受體表達下調或功能改變，從而產生耐受性和依賴性。此外，μ型阿片受體還與多種疾病相關，如慢性疼痛、焦慮癥、抑郁癥等。
由于μ型阿片受體在疼痛治療和成癮方面的作用，成為藥物研發的重要靶點。目前，已有多種μ型阿片受體激動劑和拮抗劑被開發出來，用于鎮痛和治療成癮性疾病。例如，嗎啡、海洛因等阿片類藥物是μ型阿片受體激動劑，可以產生強大的鎮痛效果，但也容易導致成癮。而納洛酮等μ型阿片受體拮抗劑則可以用于治療阿片類藥物成癮。此外，研究人員也在探索靶向μ型阿片受體的新型藥物，以期提高療效并降低副作用。
熱銷產品
Recombinant Human Mu-type opioid receptor (OPRM1) (CSB-CF016361HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
OPRM1 Antibody (CSB-PA016361LA01HU)
驗證數據
Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate
All lanes: OPRM1 antibody at 2.9µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 44, 50, 48, 46, 56, 35, 37, 34, 14, 11, 21 kDa
Observed band size: 45 kDa
IHC image of CSB-PA016361LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA016361LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Mu-type opioid receptor(OPRM1) ELISA kit (CSB-EL016361HU)
驗證數據
貨號：CSB-EL016361HU
規格：96T/48T
靈敏度：7.81 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
OPRM1 Antibodies
OPRM1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA148947 | OPRM1 (Ab-375) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA168551 | Phospho-OPRM1 (Ser375) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000744 | Phospho-OPRM1 (S375) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003264 | OPRM1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020192 | OPRM1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA016361LA01HU | OPRM1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA016361LB01HU | OPRM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA016361LC01HU | OPRM1 Antibody, FITC conjugated | Human | |
| CSB-PA016361LD01HU | OPRM1 Antibody, Biotin conjugated | Human | ELISA |
OPRM1 Proteins
OPRM1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016361BO1 CSB-EP016361BO1 CSB-BP016361BO1 CSB-MP016361BO1 CSB-EP016361BO1-B |
Recombinant Bovine Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016361BO | Recombinant Bovine Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Cavia porcellus (Guinea pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016361GU1 CSB-EP016361GU1 CSB-BP016361GU1 CSB-MP016361GU1 CSB-EP016361GU1-B |
Recombinant Guinea pig Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016361GU | Recombinant Guinea pig Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016361HU1 CSB-EP016361HU1 CSB-BP016361HU1 CSB-MP016361HU1 CSB-EP016361HU1-B |
Recombinant Human Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016361HU | Recombinant Human Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
| CSB-MP016361HU | Recombinant Human Mu-type opioid receptor (OPRM1)-VLPs | Mammalian cell |
OPRM1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016361MO1 CSB-EP016361MO1 CSB-BP016361MO1 CSB-MP016361MO1 CSB-EP016361MO1-B |
Recombinant Mouse Mu-type opioid receptor (Oprm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016361MO | Recombinant Mouse Mu-type opioid receptor (Oprm1) | in vitro E.coli expression system |
OPRM1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP016361RA1 CSB-EP016361RA1 CSB-BP016361RA1 CSB-MP016361RA1 CSB-EP016361RA1-B |
Recombinant Rat Mu-type opioid receptor (Oprm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016361RA | Recombinant Rat Mu-type opioid receptor (Oprm1) | in vitro E.coli expression system |
OPRM1 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP689277SWC1 CSB-EP689277SWC1 CSB-BP689277SWC1 CSB-MP689277SWC1 CSB-EP689277SWC1-B |
Recombinant Saimiri boliviensis boliviensis Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF689277SWC | Recombinant Saimiri boliviensis boliviensis Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP702438EQV1 CSB-EP702438EQV1 CSB-BP702438EQV1 CSB-MP702438EQV1 CSB-EP702438EQV1-B |
Recombinant Pan troglodytes Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF702438EQV | Recombinant Pan troglodytes Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842513PI1 CSB-EP842513PI1 CSB-BP842513PI1 CSB-MP842513PI1 CSB-EP842513PI1-B |
Recombinant Pig Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF842513PI | Recombinant Pig Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842565MOV1 CSB-EP842565MOV1 CSB-BP842565MOV1 CSB-MP842565MOV1 CSB-EP842565MOV1-B |
Recombinant Macaca fascicularis Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF842565MOV | Recombinant Macaca fascicularis Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP881999MOW1 CSB-EP881999MOW1 CSB-BP881999MOW1 CSB-MP881999MOW1 CSB-EP881999MOW1-B |
Recombinant Macaca mulatta Mu-type opioid receptor (OPRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF881999MOW | Recombinant Macaca mulatta Mu-type opioid receptor (OPRM1) | in vitro E.coli expression system |
OPRM1 ELISA Kit
OPRM1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL016361HU | Human Mu-type opioid receptor(OPRM1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |
