NRP1
神經(jīng)纖毛蛋白（Neuropilin-1，簡(jiǎn)稱NRP1）是一種單次跨膜、非酪氨酸激酶表面糖蛋白。NRP1最初被發(fā)現(xiàn)作為正常胚胎發(fā)育、軸突引導(dǎo)和血管形成所必需的神經(jīng)元和內(nèi)皮細(xì)胞受體，也在參與關(guān)鍵免疫功能的多種免疫細(xì)胞類型中表達(dá)。現(xiàn)有的研究表明，NRP1在癌癥患者的調(diào)節(jié)性T細(xì)胞中升高，提示其可能是癌癥免疫治療的靶點(diǎn)。在COVID-19研究中，人們發(fā)現(xiàn)NRP1能夠與S蛋白結(jié)合增強(qiáng)新冠病毒的感染能力。通過(guò)單抗對(duì)NRP1進(jìn)行阻斷，實(shí)驗(yàn)結(jié)果證明，新冠病毒的感染性得到明顯下降。另外，NRP1能夠與廣泛的配體結(jié)合，如信號(hào)素3A（Sema3A）、生長(zhǎng)因子VEGF1、轉(zhuǎn)化生長(zhǎng)因子β、血小板衍生生長(zhǎng)因子C和D、和C-Met等等。越來(lái)越多的文獻(xiàn)表明，NRP1是癌癥免疫治療中一種獨(dú)特的免疫調(diào)節(jié)劑。在TME中，NRP1內(nèi)在地調(diào)節(jié)Treg細(xì)胞和CD8+T細(xì)胞功能，共同阻礙抗腫瘤免疫。因此，NRP1在腫瘤中作為一個(gè)關(guān)鍵的免疫調(diào)節(jié)劑具有誘人的開(kāi)發(fā)前景。
Recombinant Human NRP1 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized human VEGF165 (CSB-MP025833HU(F4)) at 2 μg/ml can bind human NRP1, the EC50 is 22.68-34.55 ng/ml.
NRP1 Antibodies
NRP1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA016091GA01HU | NRP1 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA016091ESR1HU | NRP1 Antibody | Human | ELISA, IHC |
| CSB-PA003418 | NRP1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA005809 | NRP1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA904747 | NRP1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA016091MA1HU | NRP1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
NRP1 Proteins
NRP1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP016091CH CSB-EP016091CH CSB-BP016091CH CSB-MP016091CH CSB-EP016091CH-B |
Recombinant Chicken Neuropilin-1 (NRP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP016091MO CSB-EP016091MO CSB-BP016091MO CSB-MP016091MO CSB-EP016091MO-B |
Recombinant Mouse Neuropilin-1 (Nrp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRP1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP016091XBE CSB-EP016091XBE CSB-BP016091XBE CSB-MP016091XBE CSB-EP016091XBE-B |
Recombinant Xenopus laevis Neuropilin-1 (nrp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP016091HU CSB-BP016091HU CSB-EP016091HU-B |
Recombinant Human Neuropilin-1 (NRP1) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP016091HU | Recombinant Human Neuropilin-1 (NRP1) (Active) | Mammalian cell |
| CSB-MP016091HU(M) | Recombinant Human Neuropilin-1 (NRP1) (V179A) | Mammalian cell |
NRP1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP341354SVG CSB-EP341354SVG CSB-BP341354SVG CSB-MP341354SVG CSB-EP341354SVG-B |
Recombinant Saccharomyces cerevisiae Asparagine-rich protein (NRP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRP1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP879432RA CSB-EP879432RA CSB-BP879432RA CSB-MP879432RA CSB-EP879432RA-B |
Recombinant Rat Neuropilin-1 (Nrp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
