NOTCH2
NOTCH2，全稱(chēng)為Notch homolog 2 (Drosophila)，別名N2N，是一種與細(xì)胞分化、增殖和凋亡密切相關(guān)的蛋白質(zhì)。該蛋白在多種組織中表達(dá)，并在發(fā)育過(guò)程中發(fā)揮重要作用。NOTCH2蛋白通過(guò)與其他蛋白質(zhì)的結(jié)合，參與細(xì)胞信號(hào)傳導(dǎo)，影響細(xì)胞的命運(yùn)決定。研究表明，NOTCH2蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括癌癥、心血管疾病和神經(jīng)退行性疾病。在癌癥中，NOTCH2蛋白的異常表達(dá)或功能異常可能導(dǎo)致腫瘤細(xì)胞的增殖、侵襲和轉(zhuǎn)移。因此，針對(duì)NOTCH2蛋白的藥物研發(fā)成為癌癥治療的重要方向。目前，已有多種靶向NOTCH2蛋白的藥物進(jìn)入臨床試驗(yàn)階段，包括抗體藥物、細(xì)胞療法和基因療法等。這些藥物通過(guò)抑制NOTCH2蛋白的表達(dá)或功能，有望為相關(guān)疾病患者帶來(lái)新的治療選擇。
熱銷(xiāo)產(chǎn)品
NOTCH2 Antibody (CSB-PA015950LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015950LA01HU at dilution of 1:100
Immunofluorescence staining of MCF-7 cells with CSB-PA015950LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
NOTCH2 Antibodies
NOTCH2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA000058 | Cleaved-NOTCH2 (D1733) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020143 | Cleaved-NOTCH2 (A1734) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA020145 | Cleaved-NOTCH2 (V1697) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA633834 | NOTCH2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA964902 | NOTCH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA015950LA01HU | NOTCH2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA015950LB01HU | NOTCH2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA015950LC01HU | NOTCH2 Antibody, FITC conjugated | Human |
NOTCH2 Proteins
NOTCH2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP015950HU CSB-EP015950HU CSB-BP015950HU CSB-MP015950HU CSB-EP015950HU-B |
Recombinant Human Neurogenic locus notch homolog protein 2 (NOTCH2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP015950MO CSB-EP015950MO CSB-BP015950MO CSB-MP015950MO CSB-EP015950MO-B |
Recombinant Mouse Neurogenic locus notch homolog protein 2 (Notch2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP882539RA CSB-EP882539RA CSB-BP882539RA CSB-MP882539RA CSB-EP882539RA-B |
Recombinant Rat Neurogenic locus notch homolog protein 2 (Notch2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
