MARK2
MARK2 is a protein in humans that is encoded by MARK2 gene. Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
MARK2 Antibodies
MARK2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013497GA01HU | MARK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA211429 | MARK2 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA003194 | MARK2 Antibody | Human,Mouse,Rat,Monkey | WB, IF, ELISA |
| CSB-PA008035 | Phospho-MARK2 (T596) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008036 | MARK2 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA267095 | MARK2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA762568LA01HU | MARK2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA762568LB01HU | MARK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA762568LC01HU | MARK2 Antibody, FITC conjugated | Human | |
| CSB-PA762568LD01HU | MARK2 Antibody, Biotin conjugated | Human | ELISA |
MARK2 Proteins
MARK2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013497MO CSB-EP013497MO CSB-BP013497MO CSB-MP013497MO CSB-EP013497MO-B |
Recombinant Mouse Serine/threonine-protein kinase MARK2 (Mark2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MARK2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013497RA CSB-EP013497RA CSB-BP013497RA CSB-MP013497RA CSB-EP013497RA-B |
Recombinant Rat Serine/threonine-protein kinase MARK2 (Mark2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MARK2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP762568HU CSB-EP762568HU CSB-BP762568HU CSB-MP762568HU CSB-EP762568HU-B |
Recombinant Human Serine/threonine-protein kinase MARK2 (MARK2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
