MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2 is a protein in humans that is encoded by MAP4K2 gene. Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8.
MAP4K2 Antibodies
MAP4K2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013437GA01HU | MAP4K2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA294869 | MAP4K2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA058535 | MAP4K2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA013437LA01HU | MAP4K2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA013437LB01HU | MAP4K2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013437LC01HU | MAP4K2 Antibody, FITC conjugated | Human | |
| CSB-PA013437LD01HU | MAP4K2 Antibody, Biotin conjugated | Human | ELISA |
MAP4K2 Proteins
MAP4K2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013437MO CSB-EP013437MO CSB-BP013437MO CSB-MP013437MO CSB-EP013437MO-B |
Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP4K2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013437HU CSB-EP013437HU CSB-BP013437HU CSB-MP013437HU CSB-EP013437HU-B |
Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
