LEF1
Lymphoid enhancer-binding factor 1 is a protein in humans that is encoded by LEF1 gene. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
LEF1 Antibodies
LEF1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012856GA01HU | LEF1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA020264 | Phospho-LEF1 (S42) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA088510 | LEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA069370 | LEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA012856LA01HU | LEF1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA012856LB01HU | LEF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012856LC01HU | LEF1 Antibody, FITC conjugated | Human | |
| CSB-PA012856LD01HU | LEF1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA561630A0HU | LEF1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
LEF1 Proteins
LEF1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012856MO CSB-EP012856MO CSB-BP012856MO CSB-MP012856MO CSB-EP012856MO-B |
Recombinant Mouse Lymphoid enhancer-binding factor 1 (Lef1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEF1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012856RA CSB-EP012856RA CSB-BP012856RA CSB-MP012856RA CSB-EP012856RA-B |
Recombinant Rat Lymphoid enhancer-binding factor 1 (Lef1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LEF1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012856HU CSB-EP012856HU CSB-BP012856HU CSB-MP012856HU CSB-EP012856HU-B |
Recombinant Human Lymphoid enhancer-binding factor 1 (LEF1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
