KIF7
Kinesin-like protein KIF7is a protein in humans that is encoded by KIF7 gene. Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation.
KIF7 Antibodies
KIF7 for H, M, R
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA000220 | KIF7 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
KIF7 Proteins
KIF7 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012345MO CSB-EP012345MO CSB-BP012345MO CSB-MP012345MO CSB-EP012345MO-B |
Recombinant Mouse Kinesin-like protein KIF7 (Kif7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KIF7 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP645736HU CSB-EP645736HU CSB-BP645736HU CSB-MP645736HU CSB-EP645736HU-B |
Recombinant Human Kinesin-like protein KIF7 (KIF7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KIF7 Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP700886DKK CSB-EP700886DKK CSB-BP700886DKK CSB-MP700886DKK CSB-EP700886DKK-B |
Recombinant Dictyostelium discoideum Kinesin-related protein 7 (kif7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KIF7 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP704511DIL CSB-EP704511DIL CSB-BP704511DIL CSB-MP704511DIL CSB-EP704511DIL-B |
Recombinant Danio rerio Kinesin-like protein kif7 (kif7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
