KIF20A
KIF20A（驅(qū)動(dòng)蛋白家族成員20A）也被稱為Rab6相互作用驅(qū)動(dòng)蛋白樣蛋白或MKLP2，是一種參與細(xì)胞有絲分裂的關(guān)鍵分子馬達(dá)蛋白。KIF20A通過調(diào)控微管動(dòng)態(tài)參與胞質(zhì)分裂過程，負(fù)責(zé)將細(xì)胞膜成分與染色體分離所需的物質(zhì)定向運(yùn)輸至分裂溝區(qū)域。KIF20A在多種惡性腫瘤中異常高表達(dá)，包括肝癌、胰腺癌和三陰性乳腺癌，其過表達(dá)會(huì)加速腫瘤細(xì)胞增殖并促進(jìn)遠(yuǎn)處轉(zhuǎn)移，已成為癌癥治療的重要潛在靶點(diǎn)。目前針對(duì)該靶點(diǎn)的藥物開發(fā)聚焦于小分子抑制劑和單克隆抗體，其中日本研發(fā)的KIF20A多肽疫苗已在肝癌臨床前試驗(yàn)中顯示出抑制腫瘤生長(zhǎng)的效果，而特異性抑制劑Paprotrain等化合物正進(jìn)行抗腫瘤活性評(píng)估。KIF20A在正常組織中低表達(dá)的特性為靶向治療提供了較好的安全性窗口。
熱銷產(chǎn)品
KIF20A Antibody (CSB-PA012321LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012321LA01HU at dilution of 1:100
Immunoprecipitating KIF20A in 293 whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA012321LA01HU in 293 whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA012321LA01HU (6μg) + 293 whole cell lysate (500μg)
Lane 3: 293 whole cell lysate (10μg)
KIF20A Antibodies
KIF20A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012321GA01HU | KIF20A Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA006385 | Phospho-KIF20A (S528) Antibody | Human | WB, IHC, ELISA |
| CSB-PA006386 | KIF20A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA099632 | KIF20A Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA966542 | KIF20A Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA012321LA01HU | KIF20A Antibody | Human | ELISA, IHC, IP |
| CSB-PA012321LB01HU | KIF20A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012321LC01HU | KIF20A Antibody, FITC conjugated | Human | |
| CSB-PA012321LD01HU | KIF20A Antibody, Biotin conjugated | Human | ELISA |
KIF20A Proteins
KIF20A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012321HU CSB-EP012321HU CSB-BP012321HU CSB-MP012321HU CSB-EP012321HU-B |
Recombinant Human Kinesin-like protein KIF20A (KIF20A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
