ITGB6
整合素β6（ITGB6）是整合素家族成員之一，通常與αv亞基結(jié)合形成αvβ6復(fù)合體，主要分布于上皮細(xì)胞表面，參與調(diào)控細(xì)胞與周?chē)|(zhì)的動(dòng)態(tài)黏附過(guò)程。這種蛋白在胚胎發(fā)育、創(chuàng)傷修復(fù)及免疫調(diào)節(jié)中扮演重要角色，尤其在慢性炎癥與組織纖維化中表現(xiàn)活躍。研究發(fā)現(xiàn)，ITGB6異常活化與特發(fā)性肺纖維化、肝硬化及多種上皮源性腫瘤（如胰腺癌、頭頸鱗癌）密切相關(guān)，其過(guò)度表達(dá)可能加速病灶區(qū)域基質(zhì)重塑與異常增生。
近年來(lái)，針對(duì)ITGB6的靶向干預(yù)成為研究熱點(diǎn)。例如，單克隆抗體BG00011通過(guò)阻斷αvβ6與潛在TGF-β結(jié)合，在特發(fā)性肺纖維化的II期臨床試驗(yàn)中顯示出延緩肺功能下降的潛力。此外，小分子抑制劑如GNS-2146正探索其在抑制腫瘤轉(zhuǎn)移中的應(yīng)用，部分臨床前數(shù)據(jù)顯示其可減少胰腺癌細(xì)胞侵襲。然而，這類藥物仍面臨靶向特異性不足及組織分布局限的挑戰(zhàn)，聯(lián)合免疫療法或新型遞送系統(tǒng)的開(kāi)發(fā)成為突破方向。
熱銷(xiāo)產(chǎn)品
Recombinant Human Integrin beta-6 (ITGB6), partial (CSB-YP011890HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGB6 Recombinant Monoclonal Antibody (CSB-RA011890MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human ITGAV&ITGB6 with Anti-ITGB6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 (CSB-MP6145HU) at 2 μg/mL can bind Anti-ITGB6 recombinant antibody. The EC50 is 7.021-9.054 ng/mL.
The Binding Activity of Mouse Itgav&Itgb6 with Anti-ITGB6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Itgav&Itgb6 (CSB-MP6686MO) at 2 μg/mL can bind Anti-ITGB6 recombinant antibody. The EC50 is 3.911-4.510 ng/mL.
ITGB6 Antibodies
ITGB6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011890GA01HU | ITGB6 Antibody | Human | ELISA,WB |
| CSB-PA160596 | ITGB6 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA011890LA01HU | ITGB6 Antibody | Human, Mouse | ELISA, WB,IF |
| CSB-PA011890LB01HU | ITGB6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011890LC01HU | ITGB6 Antibody, FITC conjugated | Human | |
| CSB-PA011890LD01HU | ITGB6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011890MA1HU | ITGB6 Recombinant Monoclonal Antibody | Human, Mouse | ELISA |
ITGB6 Proteins
ITGB6 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011890GU1 CSB-EP011890GU1 CSB-BP011890GU1 CSB-MP011890GU1 CSB-EP011890GU1-B |
Recombinant Guinea pig Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011890GU | Recombinant Guinea pig Integrin beta-6 (ITGB6) | in vitro E.coli expression system |
ITGB6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP011890HU1 CSB-BP011890HU1 CSB-EP011890HU1-B |
Recombinant Human Integrin beta-6 (ITGB6), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011890HU | Recombinant Human Integrin beta-6 (ITGB6) | in vitro E.coli expression system |
| CSB-YP011890HU1 | Recombinant Human Integrin beta-6 (ITGB6), partial | Yeast |
| CSB-MP011890HU1 | Recombinant Human Integrin beta-6 (ITGB6), partial | Mammalian cell |
ITGB6 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP638458PI CSB-EP638458PI CSB-BP638458PI CSB-MP638458PI CSB-EP638458PI-B |
Recombinant Pig Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP728115RA CSB-EP728115RA CSB-BP728115RA CSB-MP728115RA CSB-EP728115RA-B |
Recombinant Rat Integrin beta-6 (Itgb6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP803017SH CSB-EP803017SH CSB-BP803017SH CSB-MP803017SH CSB-EP803017SH-B |
Recombinant Sheep Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP848316BO CSB-EP848316BO CSB-BP848316BO CSB-MP848316BO CSB-EP848316BO-B |
Recombinant Bovine Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
