Recombinant Bovine Integrin beta-6 (ITGB6), partial

中文名稱：

牛ITGB6重組蛋白
貨號：

CSB-YP848316BO
規格：
來源：

Yeast
其他：

中文名稱：

牛ITGB6重組蛋白
貨號：

CSB-EP848316BO
規格：
來源：

E.coli
其他：

中文名稱：

牛ITGB6重組蛋白
貨號：

CSB-EP848316BO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛ITGB6重組蛋白
貨號：

CSB-BP848316BO
規格：
來源：

Baculovirus
其他：

中文名稱：

牛ITGB6重組蛋白
貨號：

CSB-MP848316BO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ITGB6
Uniprot No.：

Q8SQB8
別名：

ITGB6; Integrin beta-6
種屬：

Bos taurus (Bovine)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.
基因功能參考文獻：
1. Single-nucleotide polymorphism G29A in ITGB6 (rs109075046) revealed a clear role in the incidence of foot-and-mouth disease in the studied population. PMID: 25078391
2. identified as receptor for foot-and-mouth disease virus PMID: 15331710
3. specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif. PMID: 18045932
亞細胞定位：

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
蛋白家族：

Integrin beta chain family
數據庫鏈接：

KEGG: bta:282644

STRING: 9913.ENSBTAP00000011972

UniGene: Bt.9972