ITGA4
ITGA4全稱為整合素α4，是細胞表面重要的黏附分子，常與β1或β7亞基結(jié)合形成復(fù)合蛋白，也稱作CD49d或VLA-4。這類蛋白廣泛分布于免疫細胞表面，通過調(diào)控細胞遷移參與炎癥反應(yīng)和免疫應(yīng)答，ITGA4功能異常與多發(fā)性硬化、潰瘍性結(jié)腸炎等自身免疫疾病密切相關(guān)，在腫瘤轉(zhuǎn)移過程中也表現(xiàn)出促進癌細胞擴散的特性。目前針對該蛋白的藥物開發(fā)已取得突破，例如那他珠單抗通過阻斷其活性，顯著降低多發(fā)性硬化患者的復(fù)發(fā)率，但需警惕進行性多腦白質(zhì)病等罕見副作用。近年研究還發(fā)現(xiàn)，小分子抑制劑在類風(fēng)濕關(guān)節(jié)炎模型中能有效緩解關(guān)節(jié)損傷，部分候選藥物已進入II期臨床試驗。隨著對蛋白構(gòu)象變化機制的深入解析，新一代高選擇性調(diào)節(jié)劑的開發(fā)為精準治療提供了新方向。
熱銷產(chǎn)品
Recombinant Human Integrin alpha-4 (ITGA4), partial (CSB-EP011867HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGA4 Recombinant Monoclonal Antibody (CSB-RA225859A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: ITGA4 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 115, 26 kDa
Observed band size: 140 kDa
ITGA4 Antibodies
ITGA4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011867GA01HU | ITGA4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA977888 | ITGA4 Antibody | Human | ELISA,WB |
| CSB-PA005224 | ITGA4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA011259 | Phospho-ITGA4 (S1027) Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA011260 | ITGA4 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA011867LA01HU | ITGA4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011867LB01HU | ITGA4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011867LC01HU | ITGA4 Antibody, FITC conjugated | Human | |
| CSB-PA011867LD01HU | ITGA4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA225859A0HU | ITGA4 Recombinant Monoclonal Antibody | Human | ELISA, WB |
ITGA4 Proteins
ITGA4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011867HU CSB-EP011867HU CSB-BP011867HU CSB-MP011867HU CSB-EP011867HU-B |
Recombinant Human Integrin alpha-4 (ITGA4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011867HU1 | Recombinant Human Integrin alpha-4 (ITGA4), partial | E.coli |
ITGA4 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP838629XBE CSB-EP838629XBE CSB-BP838629XBE CSB-MP838629XBE CSB-EP838629XBE-B |
Recombinant Xenopus laevis Integrin alpha-4 (itga4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA4 ELISA Kit
ITGA4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17545h | Human Integrin alpha-4(ITGA4/CD49D)ELISA kit | serum, plasma, tissue homogenates | 0.078ng/ml |
