INVS
Inversin是人體中由INVS基因編碼的一種蛋白質。它在正常腎臟發育和左右軸的建立中起著必要作用。可能作為不同Wnt信號通路之間的分子開關。通過靶向細胞質中的Disheveled（DVL1）使其被泛素蛋白酶降解，從而抑制了經典Wnt通路。這表明，在腎臟發育中，它在對抗Wnt信號抑制小管上皮細胞末期分化方面是必要的。與NPHP1、NPHP4和RPGRIP1L/NPHP8（類似物）共同參與調節腎細胞頂部結合的組織。似乎不是纖毛發生的嚴格必需品（類似）。
Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
INVS Antibodies
INVS for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011769GA01HU | INVS Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA011769LA01HU | INVS Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA011769LB01HU | INVS Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011769LC01HU | INVS Antibody, FITC conjugated | Human | |
| CSB-PA011769LD01HU | INVS Antibody, Biotin conjugated | Human | ELISA |
INVS Proteins
INVS Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011769MO CSB-EP011769MO CSB-BP011769MO CSB-MP011769MO CSB-EP011769MO-B |
Recombinant Mouse Inversin (Invs), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011769DO CSB-EP011769DO CSB-BP011769DO CSB-MP011769DO CSB-EP011769DO-B |
Recombinant Dog Inversin (INVS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011769DIL CSB-EP011769DIL CSB-BP011769DIL CSB-MP011769DIL CSB-EP011769DIL-B |
Recombinant Danio rerio Inversin (invs), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011769CH CSB-EP011769CH CSB-BP011769CH CSB-MP011769CH CSB-EP011769CH-B |
Recombinant Chicken Inversin (INVS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011769HU CSB-EP011769HU CSB-BP011769HU CSB-MP011769HU CSB-EP011769HU-B |
Recombinant Human Inversin (INVS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
