INPPL1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 is a protein in humans that is encoded by INPPL1 gene. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling.
INPPL1 Antibodies
INPPL1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA423922 | INPPL1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA244145 | INPPL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA549134 | INPPL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
INPPL1 Proteins
INPPL1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP521146HU CSB-EP521146HU CSB-BP521146HU CSB-MP521146HU CSB-EP521146HU-B |
Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INPPL1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP754192MO CSB-EP754192MO CSB-BP754192MO CSB-MP754192MO CSB-EP754192MO-B |
Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Inppl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INPPL1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP893910RA CSB-EP893910RA CSB-BP893910RA CSB-MP893910RA CSB-EP893910RA-B |
Recombinant Rat Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Inppl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
