IL26
IL26蛋白全稱為白細(xì)胞介素26，屬于IL-10細(xì)胞因子家族成員，因其主要表達(dá)于活化的T細(xì)胞和自然殺傷細(xì)胞，早期曾被稱為"NK細(xì)胞源性可溶因子"。該蛋白通過(guò)與細(xì)胞表面由IL-20R1和IL-10R2組成的異源二聚體受體結(jié)合，觸發(fā)免疫細(xì)胞活化并促進(jìn)炎性介質(zhì)釋放。研究發(fā)現(xiàn)其在黏膜免疫防御中具有雙重角色，既能通過(guò)招募中性粒細(xì)胞增強(qiáng)抗菌能力，又會(huì)過(guò)度刺激Th17細(xì)胞導(dǎo)致組織損傷。臨床證據(jù)顯示，IL26在銀屑病患者的皮損部位、克羅恩病腸道病灶以及肺結(jié)核患者的肺部肉芽腫中異常高表達(dá)，其水平與疾病活動(dòng)度呈正相關(guān)。針對(duì)該靶點(diǎn)的藥物開發(fā)尚處探索階段，已有研究嘗試通過(guò)單克隆抗體阻斷其與受體結(jié)合，或利用反義寡核苷酸抑制其產(chǎn)生。近期動(dòng)物實(shí)驗(yàn)表明，抑制IL26可顯著緩解關(guān)節(jié)炎模型的關(guān)節(jié)腫脹，但人體試驗(yàn)尚未開展。由于IL26在抗病毒免疫中的保護(hù)作用，相關(guān)治療策略需精準(zhǔn)平衡其促炎與抗感染功能的雙向調(diào)節(jié)。
熱銷產(chǎn)品
Recombinant Human Interleukin-26 (IL26) (CSB-EP873613HUc2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western blot analysis of RAT-MUSLE RAT-SPLEEN 293T SH-SY5Y using IL26 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
Human Interleukin 26,IL-26 ELISA Kit (CSB-E11716h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11716h
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測(cè)范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL26 Antibodies
IL26 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA179989 | IL26 Antibody | Human | WB, ELISA |
IL26 Proteins
IL26 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP873613HU | Recombinant Human Interleukin-26 (IL26) | Yeast |
| CSB-EP873613HU | Recombinant Human Interleukin-26 (IL26) | E.coli |
| CSB-BP873613HU CSB-MP873613HU |
Recombinant Human Interleukin-26 (IL26) | Baculovirus Mammalian cell |
| CSB-EP873613HUc2 | Recombinant Human Interleukin-26 (IL26) | E.coli |
| CSB-EP873613HU-B | Recombinant Human Interleukin-26 (IL26),Biotinylated | E.coli |
IL26 ELISA Kit
IL26 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11716h | Human Interleukin 26,IL-26 ELISA Kit | serum, urine, tissue homogenates, cell lysates, cell culture supernates | 15.6 pg/mL |
