IL17RA
IL17RA蛋白全稱為白細(xì)胞介素17受體A，也被稱為CD217或IL-17R，是IL-17家族細(xì)胞因子的主要結(jié)合受體之一。它在免疫系統(tǒng)中承擔(dān)重要角色，通過與IL-17A、IL-17F等信號分子結(jié)合，激活免疫細(xì)胞間的信息傳遞，從而調(diào)節(jié)炎癥反應(yīng)和組織損傷修復(fù)過程。IL17RA廣泛表達(dá)于上皮細(xì)胞、成纖維細(xì)胞和免疫細(xì)胞表面，尤其與中性粒細(xì)胞、Th17細(xì)胞的活化密切相關(guān)，在感染防御和慢性炎癥中發(fā)揮雙重作用。
IL17RA的異常表達(dá)與銀屑病、類風(fēng)濕性關(guān)節(jié)炎、強(qiáng)直性脊柱炎等自身免疫性疾病密切相關(guān)，其過度激活會導(dǎo)致皮膚、關(guān)節(jié)等部位出現(xiàn)持續(xù)性炎癥。近年來針對該靶點(diǎn)的藥物研發(fā)進(jìn)展顯著，全球已有多款I(lǐng)L-17抑制劑上市，例如司庫奇尤單抗通過阻斷IL-17A與受體的結(jié)合，顯著改善銀屑病患者癥狀。此外，針對IL17RA結(jié)構(gòu)域的新型抗體藥物和小分子抑制劑正處于臨床前研究階段，有望為炎癥性腸病、腫瘤微環(huán)境調(diào)控等領(lǐng)域提供更精準(zhǔn)的治療策略。
熱銷產(chǎn)品
Recombinant Human Interleukin-17 receptor A (IL17RA), partial (Active) (CSB-AP004351HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL17RA Antibody (CSB-PA12929A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, HL60 whole cell lysate
All lanes: IL17RA antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 97, 93 kDa
Observed band size: 93 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA12929A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
IL17RA Antibodies
IL17RA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA058027 | IL17RA Antibody | Human | ELISA,WB |
| CSB-PA008440 | IL17RA Antibody | Human,Mouse | WB, ELISA |
| CSB-PA032717 | IL17RA Antibody | Human | ELISA,IHC |
| CSB-PA703502 | IL17RA Antibody | Human | ELISA,WB,IHC |
| CSB-PA12929A0Rb | IL17RA Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA12929B0Rb | IL17RA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA12929C0Rb | IL17RA Antibody, FITC conjugated | Human | |
| CSB-PA12929D0Rb | IL17RA Antibody, Biotin conjugated | Human | ELISA |
IL17RA Proteins
IL17RA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP736761MO CSB-EP736761MO CSB-BP736761MO CSB-MP736761MO CSB-EP736761MO-B |
Recombinant Mouse Interleukin-17 receptor A (Il17ra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17RA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP846617HU CSB-EP846617HU CSB-BP846617HU CSB-MP846617HU CSB-EP846617HU-B |
Recombinant Human Interleukin-17 receptor A (IL17RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP004351HU | Recombinant Human Interleukin-17 receptor A (IL17RA), partial (Active) | Mammalian cell |
IL17RA ELISA Kit
IL17RA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011602HU | Human Interleukin-17 receptor A(IL17RA) ELISA kit | serum, plasma, tissue homogenate | 9.75 pg/mL |
