IDH2
IDH2（異檸檬酸脫氫酶2）是一種線粒體酶，由α、β和γ三個(gè)亞基組成，形成α2βγ異源四聚體，并進(jìn)一步組裝成八聚體結(jié)構(gòu)。IDH2的主要功能是催化異檸檬酸氧化脫羧生成α-酮戊二酸（α-KG），同時(shí)將NADP+轉(zhuǎn)化為NADPH，參與三羧酸循環(huán)（TCA cycle），對(duì)細(xì)胞代謝和能量產(chǎn)生至關(guān)重要。NADPH作為一種抗氧化劑，有助于維持細(xì)胞氧化還原狀態(tài)的穩(wěn)定，并促進(jìn)脂肪酸等大分子的合成。IDH2參與的信號(hào)通路包括三羧酸循環(huán)、氧化還原穩(wěn)態(tài)的維持，以及與腫瘤發(fā)生發(fā)展相關(guān)的代謝途徑。IDH2的突變?cè)诩毙运柘蛋籽。ˋML）等腫瘤中較為常見(jiàn)，與腫瘤細(xì)胞的異常代謝和分化障礙有關(guān)。因此，IDH2不僅在細(xì)胞代謝中發(fā)揮關(guān)鍵作用，其突變還與腫瘤的發(fā)生發(fā)展密切相關(guān)，使其成為研究腫瘤代謝和開(kāi)發(fā)新療法的重要靶點(diǎn)。
熱銷產(chǎn)品
IDH2 Antibody (CSB-PA010990ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: IDH2 antibody at 5µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 46 kDa
Observed band size: 51 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010990ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010990ESR1HU at dilution of 1:100
IDH2 Antibodies
IDH2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010990GA01HU | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010990ESR2HU | IDH2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA010990ESR1HU | IDH2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA148538 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA586287 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
IDH2 Proteins
IDH2 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010990PI CSB-EP010990PI CSB-BP010990PI CSB-MP010990PI CSB-EP010990PI-B |
Recombinant Pig Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010990HU CSB-EP010990HU CSB-BP010990HU CSB-MP010990HU CSB-EP010990HU-B |
Recombinant Human Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010990MO CSB-EP010990MO CSB-BP010990MO CSB-MP010990MO CSB-EP010990MO-B |
Recombinant Mouse Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010990RA CSB-EP010990RA CSB-BP010990RA CSB-MP010990RA CSB-EP010990RA-B |
Recombinant Rat Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP310511DOA CSB-EP310511DOA CSB-BP310511DOA CSB-MP310511DOA CSB-EP310511DOA-B |
Recombinant Arabidopsis thaliana Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP340961SVG CSB-EP340961SVG CSB-BP340961SVG CSB-MP340961SVG CSB-EP340961SVG-B |
Recombinant Saccharomyces cerevisiae Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP528404KBK CSB-EP528404KBK CSB-BP528404KBK CSB-MP528404KBK CSB-EP528404KBK-B |
Recombinant Kluyveromyces lactis Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP680991MOV CSB-EP680991MOV CSB-BP680991MOV CSB-MP680991MOV CSB-EP680991MOV-B |
Recombinant Macaca fascicularis Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP891493SXV CSB-EP891493SXV CSB-BP891493SXV CSB-MP891493SXV CSB-EP891493SXV-B |
Recombinant Schizosaccharomyces pombe Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
