HAS1
透明質(zhì)酸合成酶1（Hyaluronan Synthase 1，簡(jiǎn)稱HAS1）是合成透明質(zhì)酸的關(guān)鍵酶之一，也被稱為HA synthase或細(xì)胞外基質(zhì)調(diào)節(jié)因子。HAS1通過(guò)催化葡萄糖醛酸和N-乙酰葡萄糖胺的聚合，生成透明質(zhì)酸分子，這種黏多糖廣泛存在于皮膚、關(guān)節(jié)液和細(xì)胞間質(zhì)中，具有維持組織水合度、促進(jìn)創(chuàng)傷修復(fù)等功能。HAS1的異常表達(dá)與多種病理過(guò)程密切相關(guān)。在腫瘤微環(huán)境中，其過(guò)度活躍可能加速癌細(xì)胞轉(zhuǎn)移，尤其在乳腺癌和前列腺癌中表現(xiàn)突出；而在類風(fēng)濕性關(guān)節(jié)炎患者中，關(guān)節(jié)滑膜細(xì)胞的HAS1活性升高會(huì)導(dǎo)致透明質(zhì)酸碎片堆積，引發(fā)炎癥反應(yīng)。近年來(lái)針對(duì)該靶點(diǎn)的藥物開(kāi)發(fā)集中在抑制劑領(lǐng)域，例如通過(guò)小分子化合物干擾酶活性，已有部分候選藥物進(jìn)入Ⅱ期臨床試驗(yàn)，用于治療纖維化疾病和特定實(shí)體瘤。此外，基于透明質(zhì)酸的皮膚填充劑和關(guān)節(jié)潤(rùn)滑劑已在臨床廣泛應(yīng)用，但其長(zhǎng)效性和穩(wěn)定性仍依賴對(duì)HAS1調(diào)控機(jī)制的深入研究。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA547529(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA547529(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, Human prostate tissue, Primary antibody: CSB-PA547529(HAS1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
HAS1 Antibodies
HAS1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA547529 | HAS1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA010139LA01HU | HAS1 Antibody | Human | ELISA, IF |
| CSB-PA010139LC01HU | HAS1 Antibody, FITC conjugated | Human | |
| CSB-PA010139LD01HU | HAS1 Antibody, Biotin conjugated | Human | ELISA |
HAS1 Proteins
HAS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010139HU1 CSB-EP010139HU1 CSB-BP010139HU1 CSB-MP010139HU1 CSB-EP010139HU1-B |
Recombinant Human Hyaluronan synthase 1 (HAS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF010139HU | Recombinant Human Hyaluronan synthase 1 (HAS1) | in vitro E.coli expression system |
