GUCY2D
GUCY2D,即鳥苷酸環化酶2D, 也稱為Retinal guanylyl cyclase 1、CORD6、GUC1A4、GUC2D、ROS-GC等。
GUCY2D屬于腺苷酸環化酶類-鳥苷酸環化酶家族,主要在視網膜的視桿細胞和視錐細胞中催化cGMP的合成,對光傳導過程中cGMP的補充起到關鍵作用,可能還參與膜相關蛋白向光感受器外節膜的運輸。
GUCY2D在cGMP生物合成、蛋白質氨基酸磷酸化、受體鳥苷酰基環化酶信號轉導途徑、細胞內信號轉導級聯、視覺感知和應答刺激中發揮作用。GUCY2D與視錐視桿營養不良6型(CORD6)和Leber先天性黑朦(LCA)相關,這些疾病均與視覺感知障礙有關。
熱銷產品
GUCY2D Antibody (CSB-PA010054LA01HU)
驗證數據

Western Blot
Positive WB detected in: U251 whole cell lysate
All lanes: GUCY2D antibody at 5.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 121 kDa
Observed band size: 121 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA010054LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
GUCY2D Antibodies
GUCY2D for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA010054GA01HU | GUCY2D Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA010054LA01HU | GUCY2D Antibody | Human | ELISA, WB, IF |
CSB-PA010054LB01HU | GUCY2D Antibody, HRP conjugated | Human | ELISA |
CSB-PA010054LD01HU | GUCY2D Antibody, Biotin conjugated | Human | ELISA |