GTF2H2
General transcription factor IIH subunit 2 is a protein in humans that is encoded by GTF2H2 gene. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
GTF2H2 Antibodies
GTF2H2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010008GA01HU | GTF2H2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA714270 | GTF2H2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009043 | GTF2H2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA618808LA01HU | GTF2H2 Antibody | Human | ELISA |
| CSB-PA618808LB01HU | GTF2H2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA618808LC01HU | GTF2H2 Antibody, FITC conjugated | Human |
GTF2H2 Proteins
GTF2H2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010008RA CSB-EP010008RA CSB-BP010008RA CSB-MP010008RA CSB-EP010008RA-B |
Recombinant Rat General transcription factor IIH subunit 2 (Gtf2h2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP618808HU CSB-EP618808HU CSB-BP618808HU CSB-MP618808HU CSB-EP618808HU-B |
Recombinant Human General transcription factor IIH subunit 2 (GTF2H2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP648789BO CSB-EP648789BO CSB-BP648789BO CSB-MP648789BO CSB-EP648789BO-B |
Recombinant Bovine General transcription factor IIH subunit 2 (GTF2H2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H2 Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP803096DKK CSB-EP803096DKK CSB-BP803096DKK CSB-MP803096DKK CSB-EP803096DKK-B |
Recombinant Dictyostelium discoideum General transcription factor IIH subunit 2 (gtf2h2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP864323MO CSB-EP864323MO CSB-BP864323MO CSB-MP864323MO CSB-EP864323MO-B |
Recombinant Mouse General transcription factor IIH subunit 2 (Gtf2h2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
