GFRA3
GDNF家族受體α3（GFRA3）是神經(jīng)營養(yǎng)因子受體家族的重要成員，常被稱為GFRα3或GDNF受體α3亞型。該蛋白主要通過與特定配體結(jié)合，協(xié)助調(diào)控神經(jīng)細(xì)胞的生長與存活，尤其在外周和中樞神經(jīng)系統(tǒng)的發(fā)育中具有關(guān)鍵作用。GFRA3功能異常被發(fā)現(xiàn)與多種疼痛綜合征密切相關(guān)，例如神經(jīng)病理性疼痛和慢性炎癥痛，患者常表現(xiàn)為痛覺過敏或異常性疼痛。在腫瘤領(lǐng)域，GFRA3的過表達(dá)可能促進(jìn)神經(jīng)母細(xì)胞瘤、甲狀腺髓樣癌等惡性腫瘤的進(jìn)展，部分研究提示其通過增強(qiáng)腫瘤細(xì)胞的侵襲能力影響預(yù)后。
針對GFRA3的藥物開發(fā)集中在疼痛治療領(lǐng)域，已有企業(yè)開發(fā)出選擇性拮抗劑進(jìn)入臨床前研究，旨在阻斷異常疼痛信號的傳導(dǎo)。在腫瘤治療方面，基于該受體設(shè)計的抗體偶聯(lián)藥物正在探索中，試圖通過靶向遞送細(xì)胞毒性物質(zhì)抑制腫瘤生長。部分已上市的多靶點激酶抑制劑（如卡博替尼）被發(fā)現(xiàn)對GFRA3相關(guān)通路存在間接調(diào)節(jié)作用，這為老藥新用提供了潛在方向。
熱銷產(chǎn)品
GFRA3 Antibody (CSB-PA009381LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009381LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009381LA01HU at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA009381LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GFRA3 Antibodies
GFRA3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA037992 | GFRA3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA198099 | GFRA3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA009381LA01HU | GFRA3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA009381LB01HU | GFRA3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009381LC01HU | GFRA3 Antibody, FITC conjugated | Human | |
| CSB-PA009381LD01HU | GFRA3 Antibody, Biotin conjugated | Human | ELISA |
GFRA3 Proteins
GFRA3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009381HU CSB-EP009381HU CSB-BP009381HU CSB-MP009381HU CSB-EP009381HU-B |
Recombinant Human GDNF family receptor alpha-3 (GFRA3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
