EIF2AK2
Interferon-induced, double-stranded RNA-activated protein kinase is a protein in humans that is encoded by EIF2AK2 gene. IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.
EIF2AK2 Antibodies
EIF2AK2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007511GA01HU | EIF2AK2 Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA572393 | Phospho-EIF2AK2 (Thr446) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA035578 | Phospho-EIF2AK2 (Thr451) Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA168179 | EIF2AK2 (Ab-446) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA028534 | EIF2AK2 (Ab-451) Antibody | Human,Mouse | ELISA,IHC,IF |
| CSB-PA003809 | EIF2AK2 Antibody | Human | WB, IHC, ELISA |
| CSB-PA040003 | Phospho-EIF2AK2 (T446) Antibody | Human | WB, ELISA |
| CSB-PA040004 | Phospho-EIF2AK2 (T451) Antibody | Human | IHC, ELISA |
| CSB-PA040005 | Phospho-EIF2AK2 (T258) Antibody | Human | WB, IHC, ELISA |
| CSB-PA040006 | EIF2AK2 Antibody | Human | WB, IHC, ELISA |
| CSB-PA040007 | EIF2AK2 Antibody | Human | IHC, ELISA |
| CSB-PA826977 | EIF2AK2 Antibody | Human | ELISA,IHC |
| CSB-RA007511A446phHU | Phospho-EIF2AK2 (T446) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA007511LA01HU | EIF2AK2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA007511LB01HU | EIF2AK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007511LC01HU | EIF2AK2 Antibody, FITC conjugated | Human | |
| CSB-PA007511LD01HU | EIF2AK2 Antibody, Biotin conjugated | Human | ELISA |
EIF2AK2 Proteins
EIF2AK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007511MO CSB-EP007511MO CSB-BP007511MO CSB-MP007511MO CSB-EP007511MO-B |
Recombinant Mouse Interferon-induced, double-stranded RNA-activated protein kinase (Eif2ak2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF2AK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007511HU | Recombinant Human Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) | Yeast |
| CSB-EP007511HU | Recombinant Human Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) | E.coli |
| CSB-MP007511HU CSB-EP007511HU-B |
Recombinant Human Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) | Mammalian cell In Vivo Biotinylation in E.coli |
EIF2AK2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723560RA CSB-EP723560RA CSB-BP723560RA CSB-MP723560RA CSB-EP723560RA-B |
Recombinant Rat Interferon-induced, double-stranded RNA-activated protein kinase (Eif2ak2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
