DIABLO
DIABLO，即細(xì)胞凋亡誘導(dǎo)因子SMAC模擬蛋白，別名DBOH、DFNA64、SMAC3，由DIABLO基因編碼。它是一種位于線粒體間隙的蛋白質(zhì)，在細(xì)胞應(yīng)激反應(yīng)中發(fā)揮作用。DIABLO的作用機(jī)制是通過(guò)模擬SMAC蛋白的功能，促進(jìn)細(xì)胞凋亡，抑制IAPs（凋亡抑制蛋白）的活性，從而推動(dòng)細(xì)胞程序性死亡。DIABLO在細(xì)胞對(duì)氧化應(yīng)激、DNA損傷和其他形式的細(xì)胞壓力的響應(yīng)中具有重要作用。生物學(xué)意義上，DIABLO參與調(diào)控細(xì)胞生存與死亡的平衡，其異常表達(dá)與多種疾病有關(guān)，包括癌癥、神經(jīng)退行性疾病等，是細(xì)胞凋亡研究和相關(guān)疾病治療中的潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Diablo homolog, mitochondrial (DIABLO) (CSB-EP865113HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DIABLO Antibody (CSB-PA865113LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA865113LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA865113LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DIABLO Antibodies
DIABLO for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA006888GA01HU | DIABLO Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA592293 | DIABLO Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA966330 | DIABLO Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA865113LA01HU | DIABLO Antibody | Human | ELISA, IHC, IF |
DIABLO Proteins
DIABLO Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP389935XBE CSB-EP389935XBE CSB-BP389935XBE CSB-MP389935XBE CSB-EP389935XBE-B |
Recombinant Xenopus laevis Diablo homolog, mitochondrial (diablo) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIABLO Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP611189XBF CSB-EP611189XBF CSB-BP611189XBF CSB-MP611189XBF CSB-EP611189XBF-B |
Recombinant Xenopus tropicalis Diablo homolog, mitochondrial (diablo) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIABLO Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP732738PYX CSB-EP732738PYX CSB-BP732738PYX CSB-MP732738PYX CSB-EP732738PYX-B |
Recombinant Pongo abelii Diablo homolog, mitochondrial (DIABLO) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIABLO Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP865113HU CSB-BP865113HU CSB-MP865113HU CSB-EP865113HU-B |
Recombinant Human Diablo homolog, mitochondrial (DIABLO) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP865113HU | Recombinant Human Diablo homolog, mitochondrial (DIABLO) | E.coli |
DIABLO Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP878067MO CSB-EP878067MO CSB-BP878067MO CSB-MP878067MO CSB-EP878067MO-B |
Recombinant Mouse Diablo homolog, mitochondrial (Diablo) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
