DDB2
DNA damage-binding protein 2 is a protein in humans that is encoded by DDB2 gene. Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
DDB2 Antibodies
DDB2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006582GA01HU | DDB2 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA846067LA01HU | DDB2 Antibody | Human, Rat, Mouse | ELISA, WB |
| CSB-PA846067LB01HU | DDB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA846067LC01HU | DDB2 Antibody, FITC conjugated | Human | |
| CSB-RA442393A0HU | DDB2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
DDB2 Proteins
DDB2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP604366BO CSB-EP604366BO CSB-BP604366BO CSB-MP604366BO CSB-EP604366BO-B |
Recombinant Bovine DNA damage-binding protein 2 (DDB2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDB2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP652125DIL CSB-EP652125DIL CSB-BP652125DIL CSB-MP652125DIL CSB-EP652125DIL-B |
Recombinant Danio rerio DNA damage-binding protein 2 (ddb2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDB2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP714898XBF CSB-EP714898XBF CSB-BP714898XBF CSB-MP714898XBF CSB-EP714898XBF-B |
Recombinant Xenopus tropicalis DNA damage-binding protein 2 (ddb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDB2 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP723169CH CSB-EP723169CH CSB-BP723169CH CSB-MP723169CH CSB-EP723169CH-B |
Recombinant Chicken DNA damage-binding protein 2 (DDB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDB2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP740641DOA CSB-EP740641DOA CSB-BP740641DOA CSB-MP740641DOA CSB-EP740641DOA-B |
Recombinant Arabidopsis thaliana Protein DAMAGED DNA-BINDING 2 (DDB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDB2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP846067HU CSB-BP846067HU CSB-MP846067HU CSB-EP846067HU-B |
Recombinant Human DNA damage-binding protein 2 (DDB2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP846067HU | Recombinant Human DNA damage-binding protein 2 (DDB2) | E.coli |
DDB2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP858124MO CSB-EP858124MO CSB-BP858124MO CSB-MP858124MO CSB-EP858124MO-B |
Recombinant Mouse DNA damage-binding protein 2 (Ddb2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
