CUL4B
Cullin-4B is a protein in humans that is encoded by CUL4B gene. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism.
CUL4B Antibodies
CUL4B for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006222GA01HU | CUL4B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA615708ESR1HU | CUL4B Antibody | Human | ELISA, IHC |
| CSB-PA005106 | CUL4B Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA870647 | CUL4B Antibody | Human,Mouse | ELISA,WB |
| CSB-PA444901 | CUL4B Antibody | Human,Mouse | ELISA,IHC |
CUL4B Proteins
CUL4B Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006222MO CSB-EP006222MO CSB-BP006222MO CSB-MP006222MO CSB-EP006222MO-B |
Recombinant Mouse Cullin-4B (Cul4b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CUL4B Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP615708HU CSB-EP615708HU CSB-BP615708HU CSB-MP615708HU CSB-EP615708HU-B |
Recombinant Human Cullin-4B (CUL4B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
