CTSL

組織蛋白酶L（CTSL）是一種在人體內發揮重要作用的蛋白酶。它的全稱是cathepsin L，常見的別名包括CTSL1和MEP。CTSL蛋白主要存在于溶酶體中，負責細胞內蛋白質的分解代謝。它能夠水解多種底物，包括膠原蛋白、彈性蛋白和α-1蛋白酶抑制劑等，這些底物與多種生理過程密切相關。例如，CTSL參與抗原加工和提呈，這對于免疫系統的正常運作至關重要；它還與細胞凋亡、細胞分化以及腫瘤的發生發展有關。研究表明，CTSL在多種疾病中發揮作用，包括癌癥、心血管疾病和神經系統疾病等。因此，CTSL成為藥物研發的重要靶點。目前，已有多種CTSL抑制劑被開發出來，用于治療癌癥、病毒感染等疾病。其中，Phelix Therapeutics公司研發的cathepsin L inhibitors是一種針對CTSL的小分子藥物，正在用于治療冠狀病毒感染。此外，還有研究表明，CTSL抑制劑在抗腫瘤、抗病毒等方面具有潛在的應用價值。

熱銷產品

Recombinant Human Procathepsin L (CTSL) (Active) (CSB-MP006193HU(A4))

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC, The specific activity is >32000 pmol/ min/μg.

CTSL Recombinant Monoclonal Antibody (CSB-RA006193MA1HU)

驗證數據

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of NIH/3T3 cell with CSB-RA006193MA1HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CTSL Antibody (CSB-PA11499A0Rb)

驗證數據

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA11499A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA11499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CTSL Antibody

CTSL Protein

CTSL ELISA Kit

CTSL Antibodies

CTSL for Chlorocebus aethiops

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA006193LA01DSU	CTSL Antibody	Chlorocebus aethiops, Human	ELISA, WB

CTSL for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA000034	Cleaved-CTSL (T288) Antibody	Human	WB, ELISA
CSB-PA004835	CTSL Antibody	Human	WB, ELISA
CSB-PA996311	CTSL Antibody	Human	ELISA,IHC
CSB-PA092272	CTSL Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA11499A0Rb	CTSL Antibody	Human	ELISA, IHC, IF
CSB-RA006193MA1HU	CTSL Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF

CTSL Proteins

CTSL Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP006193CA CSB-EP006193CA CSB-BP006193CA CSB-MP006193CA CSB-EP006193CA-B	Recombinant Cat Cathepsin L1 (CTSL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP006193BO CSB-EP006193BO CSB-BP006193BO CSB-MP006193BO CSB-EP006193BO-B	Recombinant Bovine Cathepsin L1 (CTSL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP006193MO CSB-BP006193MO CSB-MP006193MO CSB-EP006193MO-B	Recombinant Mouse Cathepsin L1 (Ctsl1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006193MO	Recombinant Mouse Cathepsin L1 (Ctsl1), partial	E.coli

CTSL Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP006193RA CSB-EP006193RA CSB-BP006193RA CSB-MP006193RA CSB-EP006193RA-B	Recombinant Rat Procathepsin L (Ctsl), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP006193HU CSB-EP006193HU CSB-BP006193HU CSB-MP006193HU CSB-EP006193HU-B	Recombinant Human Cathepsin L1 (CTSL1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP006193HU(A4)	Recombinant Human Procathepsin L (CTSL) (Active)	Mammalian cell

CTSL Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP006193CH CSB-EP006193CH CSB-BP006193CH CSB-MP006193CH CSB-EP006193CH-B	Recombinant Chicken Cathepsin L1 (CTSL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產品貨號	產品名稱	來源
CSB-YP006193DSU CSB-BP006193DSU CSB-MP006193DSU CSB-EP006193DSU-B	Recombinant Chlorocebus aethiops Cathepsin L1 (CTSL1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006193DSU	Recombinant Chlorocebus aethiops Cathepsin L1 (CTSL1), partial	E.coli

CTSL Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP006193DO CSB-EP006193DO CSB-BP006193DO CSB-MP006193DO CSB-EP006193DO-B	Recombinant Dog Cathepsin L1 (CTSL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP006193SH CSB-EP006193SH CSB-BP006193SH CSB-MP006193SH CSB-EP006193SH-B	Recombinant Sheep Cathepsin L1 (CTSL)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSL Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP006193PI CSB-EP006193PI CSB-BP006193PI CSB-MP006193PI CSB-EP006193PI-B	Recombinant Pig Cathepsin L1 (CTSL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli