CTNNB1
CTNNB1，別名Armadillo、NEDSDV、MRD19、EVR7等。CTNNB1基因位于3號(hào)染色體上，編碼的蛋白質(zhì)β-連環(huán)蛋白是細(xì)胞黏附復(fù)合物的重要成分，在上皮細(xì)胞中形成粘附連接并介導(dǎo)多種組織的細(xì)胞間粘附。CTNNB1在Wnt信號(hào)通路中扮演關(guān)鍵角色，控制細(xì)胞生長(zhǎng)和分化。在沒(méi)有Wnt信號(hào)時(shí)，β-連環(huán)蛋白被磷酸化后泛素化，并被蛋白酶體降解。Wnt信號(hào)存在時(shí)，β-連環(huán)蛋白積累并在細(xì)胞核內(nèi)與TCF/LEF家族轉(zhuǎn)錄因子結(jié)合，激活下游基因表達(dá)。CTNNB1的突變或異常激活與多種腫瘤的發(fā)生發(fā)展有關(guān)，包括結(jié)直腸癌、卵巢癌、肝細(xì)胞癌等，是腫瘤治療的重要靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
CTNNB1 Recombinant Monoclonal Antibody (CSB-RA155605A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
CTNNB1 Antibodies
CTNNB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA00174A0Rb | CTNNB1 Antibody | Human | ELISA, WB, IHC, IF, IP |
| CSB-PA00174B0Rb | CTNNB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006169GA01HU | CTNNB1 Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB,IHC |
| CSB-PA271248 | Phospho-CTNNB1 (Thr41/Ser45) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA978882 | Phospho-CTNNB1 (Ser33) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA596316 | Phospho-CTNNB1 (Ser37) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA084843 | CTNNB1 (Ab-41/45) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA271206 | CTNNB1 (Ab-33) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA118626 | CTNNB1 (Ab-37) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA134662 | CTNNB1 (Ab-654) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA931695 | CTNNB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA150703 | Phospho-CTNNB1 (Tyr333) Antibody | Human | ELISA,WB,IHC |
| CSB-PA029484 | Phospho-CTNNB1 (Tyr489) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA915531 | CTNNB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA064130 | Phospho-CTNNB1 (Tyr670) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000489 | Phospho-CTNNB1 (S37) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA000490 | Phospho-CTNNB1 (T41/S45) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA000756 | Phospho-CTNNB1 (S552) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001269 | CTNNB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA001271 | CTNNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001272 | CTNNB1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA001283 | CTNNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001291 | CTNNB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA001292 | CTNNB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007419 | Phospho-CTNNB1 (S33) Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA007420 | Phospho-CTNNB1 (Y654) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007422 | Phospho-CTNNB1 (Y489) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA007423 | CTNNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA080139 | CTNNB1 Antibody | Mouse,Rat | WB |
| CSB-RA006169A33phHU | Phospho-CTNNB1 (S33/S37) Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-MA907551 | CTNNB1 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA155605A0HU | CTNNB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA006169MA1HU | CTNNB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
CTNNB1 for H, M, R
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-MA000223 | CTNNB1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CTNNB1 for Human, Mouse, Rat
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-MA080197 | CTNNB1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CTNNB1 Proteins
CTNNB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006169HU | Recombinant Human Catenin beta-1 (CTNNB1) | Yeast |
| CSB-EP006169HU | Recombinant Human Catenin beta-1 (CTNNB1) | E.coli |
| CSB-BP006169HU CSB-MP006169HU CSB-EP006169HU-B |
Recombinant Human Catenin beta-1 (CTNNB1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006169HUa0 | Recombinant Human Catenin beta-1 (CTNNB1) | E.coli |
CTNNB1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP335181XBE CSB-EP335181XBE CSB-BP335181XBE CSB-MP335181XBE CSB-EP335181XBE-B |
Recombinant Xenopus laevis Catenin beta (ctnnb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTNNB1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP610827BO CSB-EP610827BO CSB-BP610827BO CSB-MP610827BO CSB-EP610827BO-B |
Recombinant Bovine Catenin beta-1 (CTNNB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTNNB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP892984RA CSB-EP892984RA CSB-BP892984RA CSB-MP892984RA CSB-EP892984RA-B |
Recombinant Rat Catenin beta-1 (Ctnnb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CTNNB1 ELISA Kit
CTNNB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E08963h | Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 3.9 pg/mL |
CTNNB1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E11307m | Mouse β-catenin,β-cat ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
