CRTAM
CRTAM（CD355）是免疫球蛋白超家族（Ig-SF）的新成員，同時也是nectin樣蛋白超家族的成員。它作為細胞表面跨膜蛋白，在免疫系統的形成、應答和細胞交互中扮演重要角色。CRTAM在活化的人NK細胞、CD8+ T細胞和CD4+ T細胞子集上表達，參與細胞粘附、極性和增殖，并調節淋巴細胞功能，如促進TCD8+細胞在淋巴結內的粘附和保留。 CRTAM與多種疾病關聯，包括炎癥、哮喘、惡性間皮瘤和某些腫瘤疾病。CRTAM能夠影響CD4+ T細胞的極化，促進CD4+ T細胞的進一步分化，并增強細胞因子的分泌能力。此外，CRTAM在免疫過程中對NK細胞殺傷腫瘤細胞起到關鍵作用，呈現出潛在的腫瘤靶向策略。CRTAM還可以與Necl-2相互作用，在體外促進NK細胞的細胞毒性和CD8+ T細胞的IFN-γ分泌，以及在體內NK細胞介導的對表達Necl-2的腫瘤的排斥反應。 CRTAM的表達受到嚴格的調控，主要表達于激活的免疫細胞上。在健康人的外周血單個核細胞（PBMC）中，CRTAM的表達量很低，但在哮喘病人的PBMC中高表達。CRTAM的啟動子與IL-2一樣，受到AP-1轉錄因子的調控。CRTAM激活后會刺激CD8+ T細胞分泌IFN-γ，并增強CD8+ T細胞和NK細胞的殺傷能力。
熱銷產品
● Recombinant Mouse Cytotoxic and regulatory T-cell molecule (Crtam), partial (Active)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Cadm1(CSB-MP004425MO) at 2μg/mL can bind Mouse Crtam，the EC50 is 54.36 -61.77 ng/mL.
● Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CRTAM at 2μg/mL can bind Human CADM1(CSB-MP004425HUd9)，the EC50 is 2.277-2.649 ng/mL.
CRTAM Antibodies
CRTAM for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA243691 | CRTAM Antibody | Human | ELISA,IHC |
| CSB-PA725805 | CRTAM Antibody | Human | ELISA,IHC |
CRTAM Proteins
CRTAM Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005998HU1 CSB-EP005998HU1 CSB-BP005998HU1 CSB-EP005998HU1-B |
Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF005998HU | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM) | in vitro E.coli expression system |
| CSB-AP005441HU | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active) | Mammalian cell |
| CSB-MP005998HU1d7 | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active) | Mammalian cell |
| CSB-MP005998HU1 | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial | Mammalian cell |
CRTAM Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP614820MO CSB-EP614820MO CSB-BP614820MO CSB-EP614820MO-B |
Recombinant Mouse Cytotoxic and regulatory T-cell molecule (Crtam), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CRTAM ELISA Kit
CRTAM ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005998HU | Human Cytotoxic and regulatory T-cell molecule(CRTAM) ELISA kit | serum, plasma, tissue homogenate | 0.039ng/ml |
