COL2A1
COL2A1全稱(chēng)為膠原蛋白II型α1鏈，是構(gòu)成軟骨組織的主要成分之一。這種膠原蛋白在胚胎發(fā)育階段主導(dǎo)骨骼和關(guān)節(jié)的形成，成年后則集中分布于眼睛玻璃體、椎間盤(pán)和關(guān)節(jié)軟骨中，通過(guò)交織成網(wǎng)狀結(jié)構(gòu)維持組織的彈性和承重能力。COL2A1異常表達(dá)或結(jié)構(gòu)缺陷會(huì)直接影響軟骨完整性，例如在斯蒂克勒綜合征中，患者因膠原纖維排列紊亂出現(xiàn)視網(wǎng)膜脫離和關(guān)節(jié)病變；而在遺傳性骨關(guān)節(jié)炎中，COL2A1的突變會(huì)導(dǎo)致軟骨過(guò)早退化，引發(fā)關(guān)節(jié)疼痛和活動(dòng)受限。近年來(lái)針對(duì)II型膠原蛋白的研究聚焦于再生醫(yī)學(xué)領(lǐng)域，例如利用三維生物支架結(jié)合患者自體干細(xì)胞，促進(jìn)損傷軟骨的修復(fù)。此外，一些基于膠原蛋白片段的多肽藥物已進(jìn)入臨床試驗(yàn)階段，旨在通過(guò)調(diào)節(jié)炎癥反應(yīng)延緩關(guān)節(jié)退變。自然界中的鯊魚(yú)軟骨提取物也曾被探索用于輔助治療，但其療效尚未得到充分驗(yàn)證。
熱銷(xiāo)產(chǎn)品
COL2A1 Antibody (CSB-PA005739ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Collagen alpha-1 (II) chain antibody at 10μg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 142, 135, 30 kDa
Observed band size: 142 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA005739ESR2HU at dilution of 1:100
Human Collagen alpha-1(II) chain (COL2A1) ELISA kit (CSB-EL005739HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL005739HU
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
COL2A1 Antibodies
COL2A1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA005739ESR2HU | COL2A1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA005739ESR1HU | COL2A1 Antibody | Human | ELISA, IHC |
| CSB-PA593434 | COL2A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA255449 | COL2A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA001745 | COL2A1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA437981 | COL2A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-MA964039 | COL2A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA217046 | COL2A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA768371 | COL2A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA186977 | COL2A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA397245 | COL2A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA17772A0Rb | COL2A1 Antibody | Human | ELISA, IHC |
| CSB-PA17772B0Rb | COL2A1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA17772C0Rb | COL2A1 Antibody, FITC conjugated | Human | |
| CSB-PA17772D0Rb | COL2A1 Antibody, Biotin conjugated | Human | ELISA |
COL2A1 Proteins
COL2A1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005739MO CSB-EP005739MO CSB-BP005739MO CSB-MP005739MO CSB-EP005739MO-B |
Recombinant Mouse Collagen alpha-1 (II) chain (Col2a1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005739BO CSB-EP005739BO CSB-BP005739BO CSB-MP005739BO CSB-EP005739BO-B |
Recombinant Bovine Collagen alpha-1 (II) chain (COL2A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005739HU CSB-EP005739HU CSB-BP005739HU CSB-MP005739HU CSB-EP005739HU-B |
Recombinant Human Collagen alpha-1 (II) chain (COL2A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005739RA CSB-EP005739RA CSB-BP005739RA CSB-MP005739RA CSB-EP005739RA-B |
Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP005739CH CSB-EP005739CH CSB-BP005739CH CSB-MP005739CH CSB-EP005739CH-B |
Recombinant Chicken Collagen alpha-1 (II) chain (COL2A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP747407XBF CSB-EP747407XBF CSB-BP747407XBF CSB-MP747407XBF CSB-EP747407XBF-B |
Recombinant Xenopus tropicalis Collagen alpha-1 (II) chain (col2a1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP838630XBE CSB-EP838630XBE CSB-BP838630XBE CSB-MP838630XBE CSB-EP838630XBE-B |
Recombinant Xenopus laevis Collagen alpha-1 (II) chain (col2a1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
COL2A1 ELISA Kit
COL2A1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005739HU | Human Collagen alpha-1(II) chain (COL2A1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
