CD3G
CD3γ鏈?zhǔn)荰細(xì)胞受體復(fù)合物的核心組成單元，常被簡稱為CD3γ或T3G。它與CD3δ、CD3ε等亞基共同形成跨膜蛋白簇，協(xié)助T細(xì)胞識(shí)別抗原信號(hào)并啟動(dòng)免疫應(yīng)答。該蛋白在胸腺細(xì)胞發(fā)育中不可或缺，其功能缺陷可導(dǎo)致重癥聯(lián)合免疫缺陷病（SCID），表現(xiàn)為反復(fù)感染和免疫系統(tǒng)崩潰。CD3γ的異常表達(dá)還與T細(xì)胞淋巴瘤、系統(tǒng)性紅斑狼瘡等疾病存在關(guān)聯(lián)。在治療領(lǐng)域，基于CD3靶點(diǎn)的雙特異性抗體藥物已取得突破性進(jìn)展，例如貝林妥歐單抗通過同時(shí)結(jié)合CD3與腫瘤抗原，可引導(dǎo)T細(xì)胞精準(zhǔn)殺傷惡性細(xì)胞，目前已獲批用于白血病臨床治療。此外，利用CD3γ構(gòu)建的CAR-T療法在實(shí)體瘤研究中展現(xiàn)出潛力，部分項(xiàng)目已進(jìn)入Ⅱ期臨床試驗(yàn)。
熱銷產(chǎn)品
Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial (CSB-EP004933HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD3G Antibody (CSB-PA004933LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, Rat stomach tissue
All lanes: CD3G antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA004933LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CD3G Antibodies
CD3G for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004933GA01HU | CD3G Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004933LA01HU | CD3G Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-PA004933LD01HU | CD3G Antibody, Biotin conjugated | Human | ELISA |
CD3G Proteins
CD3G Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004933MO1 CSB-EP004933MO1 CSB-BP004933MO1 CSB-MP004933MO1 CSB-EP004933MO1-B |
Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004933MO | Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g) | in vitro E.coli expression system |
CD3G Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004933SH CSB-EP004933SH CSB-BP004933SH CSB-MP004933SH CSB-EP004933SH-B |
Recombinant Sheep T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004933HU1 CSB-BP004933HU1 CSB-EP004933HU1-B |
Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004933HU | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G) | in vitro E.coli expression system |
| CSB-EP004933HU1 | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | E.coli |
| CSB-MP004933HU1 | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Mammalian cell |
CD3G Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP636709BO CSB-EP636709BO CSB-BP636709BO CSB-MP636709BO CSB-EP636709BO-B |
Recombinant Bovine T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP735566PI CSB-EP735566PI CSB-BP735566PI CSB-MP735566PI CSB-EP735566PI-B |
Recombinant Pig T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP737336RA CSB-EP737336RA CSB-BP737336RA CSB-MP737336RA CSB-EP737336RA-B |
Recombinant Rat T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850179MOV | Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast |
| CSB-EP850179MOV CSB-BP850179MOV CSB-MP850179MOV CSB-EP850179MOV-B |
Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
