ATR
ATR，即共濟(jì)失調(diào)毛細(xì)血管擴(kuò)張和輻射敏感綜合征相關(guān)蛋白，也稱為共濟(jì)失調(diào)毛細(xì)血管擴(kuò)張突變蛋白。它是一種在細(xì)胞周期中起關(guān)鍵作用的蛋白質(zhì)激酶，主要在細(xì)胞核中表達(dá)。ATR的作用機(jī)制是通過感知DNA復(fù)制過程中的異常，如單鏈DNA（ssDNA）的產(chǎn)生，進(jìn)而激活多個(gè)下游信號通路，包括CHK1和CHK2等。這些信號通路參與細(xì)胞周期的檢查點(diǎn)控制，確保DNA復(fù)制的準(zhǔn)確性和完整性。在信號傳導(dǎo)過程中，ATR通過磷酸化多種底物蛋白，促進(jìn)細(xì)胞周期停滯，DNA修復(fù)，以及對復(fù)制壓力的響應(yīng)。ATR對維持基因組穩(wěn)定性至關(guān)重要，其功能異常與多種疾病有關(guān)，包括癌癥、遺傳性疾病和衰老。ATR的激活有助于防止細(xì)胞因DNA損傷而發(fā)生癌變，是細(xì)胞應(yīng)對DNA損傷的重要機(jī)制之一。
熱銷產(chǎn)品
ATR Antibody (CSB-PA622666LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA622666LA01HU at dilution of 1:100
Western Blot
Positive WB detected in: Raji whole cell lysate, K562 whole cell lysate
All lanes: ATR antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 302, 295, 298 kDa
Observed band size: 302 kDa
ATR Antibodies
ATR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002433GA01HU | ATR Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA267100 | ATR (Ab-428) Antibody | Human | ELISA,IHC |
| CSB-PA058282 | Phospho-ATR (Ser428) Antibody | Human | ELISA,IHC |
| CSB-PA030127 | Phospho-ATR (S428) Antibody | Human | IHC, ELISA |
| CSB-PA030128 | ATR Antibody | Human | WB, IHC, ELISA |
| CSB-PA622666LA01HU | ATR Antibody | Human | ELISA, WB, IHC |
| CSB-PA622666LD01HU | ATR Antibody, Biotin conjugated | Human | ELISA |
ATR Proteins
ATR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP622666HU CSB-EP622666HU CSB-BP622666HU CSB-MP622666HU |
Recombinant Human Serine/threonine-protein kinase ATR (ATR), partial | Yeast E.coli Baculovirus Mammalian cell |
ATR Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP863791DOA CSB-EP863791DOA CSB-BP863791DOA CSB-MP863791DOA CSB-EP863791DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872068XBE CSB-EP872068XBE CSB-BP872068XBE CSB-MP872068XBE CSB-EP872068XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase atr (atr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872870MO CSB-EP872870MO CSB-BP872870MO CSB-MP872870MO CSB-EP872870MO-B |
Recombinant Mouse Serine/threonine-protein kinase ATR (Atr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
