ARG2
ARG2，全稱為Arginase type II，是一種在肝外組織中表達(dá)的酶，尤其在腎臟中高度表達(dá)。它也被稱為Arginase-2或ARG2，是一種參與尿素循環(huán)的酶，能夠催化精氨酸水解為鳥氨酸和尿素。ARG2蛋白在細(xì)胞內(nèi)的定位主要是在線粒體中，其功能與一氧化氮和多胺代謝密切相關(guān)。
ARG2蛋白在疾病發(fā)生發(fā)展中扮演著重要角色。研究表明，ARG2蛋白的表達(dá)異常與多種疾病相關(guān)，包括癌癥、神經(jīng)退行性疾病和免疫疾病等。例如，在癌癥中，ARG2蛋白的表達(dá)水平與腫瘤的生長和轉(zhuǎn)移密切相關(guān)；在神經(jīng)退行性疾病中，ARG2蛋白的異常表達(dá)可能導(dǎo)致神經(jīng)元死亡和神經(jīng)功能退化；在免疫疾病中，ARG2蛋白的表達(dá)異常可能影響免疫細(xì)胞的活性和功能。
針對ARG2蛋白的藥物研發(fā)也在不斷進(jìn)行中。目前，研究人員正在開發(fā)多種針對ARG2蛋白的抑制劑，以期通過抑制ARG2蛋白的表達(dá)或活性來治療相關(guān)疾病。例如，有研究表明，ARG2蛋白抑制劑可以抑制腫瘤的生長和轉(zhuǎn)移，并提高免疫治療的療效。
熱銷產(chǎn)品
Recombinant Human Arginase-2, mitochondrial (ARG2) (CSB-EP002006HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ARG2 Recombinant Monoclonal Antibody (CSB-RA216908A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA216908A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of PC-3 cell with CSB-RA216908A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 559-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Overlay Peak curve showing PC3 cells stained with CSB-RA216908A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Arginase 2(ARG2) ELISA Kit (CSB-E14913h)
驗證數(shù)據(jù)
貨號：CSB-E14913h
規(guī)格：96T/48T
靈敏度：0.12 mU/mL
檢測范圍：0.47 mU/mL-30 mU/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ARG2 Antibodies
ARG2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002006GA01HU | ARG2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002006ESR2HU | ARG2 Antibody | Human, Mouse | ELISA, WB, IHC, IP |
| CSB-PA093417 | ARG2 Antibody | Human | ELISA,WB |
| CSB-PA000920 | ARG2 Antibody | Human | WB, ELISA |
| CSB-RA216908A0HU | ARG2 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
ARG2 Proteins
ARG2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002006HU CSB-BP002006HU CSB-MP002006HU CSB-EP002006HU-B |
Recombinant Human Arginase-2, mitochondrial (ARG2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002006HU | Recombinant Human Arginase-2, mitochondrial (ARG2) | E.coli |
ARG2 ELISA Kit
ARG2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14913h | Human Arginase 2(ARG2) ELISA Kit | serum, plasma, cell culture supernates, urine, cerebrospinal fluid (CSF) | 0.12 mU/mL |
