NRG1

NRG1，即神經(jīng)調(diào)節(jié)蛋白1，別名HRG、NDF、GGF。這是一種由人類NRG1基因編碼的蛋白質(zhì)，屬于表皮生長因子（EGF）家族。NRG1主要是通過其異構(gòu)體與ErbB家族受體結(jié)合，激活多重下游信號(hào)通路，如PI3K/Akt、MAPK/ERK等，從而促進(jìn)細(xì)胞增殖、分化，抑制細(xì)胞凋亡，調(diào)節(jié)能量利用，并增強(qiáng)血管生成。NRG1的表達(dá)和功能異常與多種疾病的發(fā)生發(fā)展相關(guān)，包括腫瘤、心血管疾病、神經(jīng)精神疾病等。在腫瘤領(lǐng)域，NRG1基因融合是一種新興的、潛在的致癌驅(qū)動(dòng)因素，與多種腫瘤的發(fā)生發(fā)展相關(guān)，如非小細(xì)胞肺癌、腎癌、甲狀腺癌等。在心血管疾病中，NRG1/ErbB信號(hào)通路在心臟的發(fā)育、心肌增殖分化及心臟傳導(dǎo)系統(tǒng)的形成過程中起到了重要作用，并在心血管急慢性疾病中對(duì)心肌細(xì)胞具有保護(hù)功能。因此，NRG1被認(rèn)為是這些疾病潛在的治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) (CSB-MP016077HU1(F6))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1 at 2 μg/ml can bind human ERBB3(CSB-MP007765HU), the EC₅₀ is 18.24-23.66 ng/ml.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of MCF-7 cells is 2.626-7.598 ng/mL.

The purity of NRG1 was greater than 95% as determined by SEC-HPLC

NRG1 Antibody

NRG1 Protein

NRG1 Antibodies

NRG1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA016077GA01HU	NRG1 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA005465	NRG1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA970558	NRG1 Antibody	Human	ELISA,WB
CSB-PA940332	NRG1 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA965247	NRG1 Antibody	Human	ELISA,WB
CSB-PA09589A0Rb	NRG1 Antibody	Human	ELISA, IHC, IF
CSB-PA09589B0Rb	NRG1 Antibody, HRP conjugated	Human	ELISA
CSB-PA09589C0Rb	NRG1 Antibody, FITC conjugated	Human
CSB-PA09589D0Rb	NRG1 Antibody, Biotin conjugated	Human	ELISA

NRG1 Proteins

NRG1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP016077RA1 CSB-EP016077RA1 CSB-BP016077RA1 CSB-MP016077RA1 CSB-EP016077RA1-B	Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF016077RA	Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1)	in vitro E.coli expression system

NRG1 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP526051XBE CSB-EP526051XBE CSB-BP526051XBE CSB-MP526051XBE CSB-EP526051XBE-B	Recombinant Xenopus laevis Pro-neuregulin-1, membrane-bound isoform (nrg1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NRG1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-AP002851HU	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active)	E.Coli
CSB-AP002861HU	Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1), partial (Active)	E.Coli
CSB-AP002921HU	Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1),Partial (Active)	E.Coli
CSB-AP005731HU	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active)	E.coli
CSB-MP016077HU1(F6)	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active)	Mammalian cell
CSB-EP016077HU1	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial	E.coli
CSB-EP016077HU3(F6)	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial	E.coli
CSB-YP016077HU2(F6)	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial	Yeast
CSB-MP016077HU-WD	Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1)，Partial (Active)	Mammalian cell