KNG1
激肽原（Kininogen-1，簡稱KNG1）是人體血漿中重要的多功能糖蛋白，其高分子量形式（HMWK）和低分子量形式（LMWK）分別參與不同生理過程。該蛋白在傳統研究中被稱為Fitzgerald因子或接觸激活輔因子，是激肽系統核心成員之一。其通過釋放緩激肽等活性肽段，協調血管張力調節、凝血平衡和炎癥反應，尤其在血管內皮保護與損傷修復中具有雙向調節特性。
激肽原水平異常與遺傳性血管水腫、血栓性疾病及高血壓密切相關。在動脈粥樣硬化進程中，該蛋白既能通過抗凝作用抑制血栓形成，又會因過度激活補體系統加重炎癥反應，這種矛盾特性使其成為治療靶點研究的焦點。目前針對緩激肽受體的抑制劑（如艾替班特）已用于遺傳性血管水腫急性發作治療，而基于激肽原結構設計的抗血栓藥物正處于臨床前研究階段。近期有學者探索其修飾產物在腫瘤微環境調控中的應用，為癌癥治療提供了新思路。
熱銷產品
Recombinant Human Kininogen-1 (KNG1), partial (CSB-EP012479HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KNG1 Antibody (CSB-PA14647A0Rb)
驗證數據
Western blot
All lanes: KNG1 antibody at 2µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 48, 44 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA14647A0Rb at dilution of 1:50
Immunofluorescent analysis of HepG2 cells using CSB-PA14647A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Kininogen-1(KNG1) ELISA kit (CSB-EL012479HU)
驗證數據
貨號：CSB-EL012479HU
規格：96T/48T
靈敏度：11.75 ng/mL
檢測范圍：47 ng/mL-3000 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
KNG1 Antibodies
KNG1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA14647B0Rb | KNG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA14647D0Rb | KNG1 Antibody, Biotin conjugated | Human | ELISA, IHC |
| CSB-PA012479GA01HU | KNG1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA14647A0Rb | KNG1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA009655 | Cleaved-KNG1 (K380) Antibody | Human | WB, ELISA |
KNG1 for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012479LA01RA | Kng1 Antibody | Rat | ELISA |
KNG1 Proteins
KNG1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012479HU CSB-EP012479HU CSB-BP012479HU CSB-MP012479HU CSB-EP012479HU-B |
Recombinant Human Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012479HU | Recombinant Human Kininogen-1 (KNG1), partial | E.coli |
KNG1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012479BO CSB-EP012479BO CSB-BP012479BO CSB-MP012479BO CSB-EP012479BO-B |
Recombinant Bovine Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012479RA | Recombinant Rat Kininogen-1 (Kng1), partial | Yeast |
| CSB-EP012479RA CSB-BP012479RA CSB-MP012479RA CSB-EP012479RA-B |
Recombinant Rat Kininogen-1 (Kng1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012479MO CSB-EP012479MO CSB-BP012479MO CSB-MP012479MO CSB-EP012479MO-B |
Recombinant Mouse Kininogen-1 (Kng1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 ELISA Kit
KNG1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012479HU | Human Kininogen-1(KNG1) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 11.75 ng/mL |
KNG1 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12725r | Rat kininogen(KNG) ELISA Kit | serum, plasma, tissue homogenates | 0.097 ng/ml |
