NEU1 Antibody

中文名稱：

NEU1兔多克隆抗體
貨號(hào)：

CSB-PA17249A0Rb
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA17249A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA17249A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA17249A0Rb at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NEU1 Polyclonal antibody
Uniprot No.：

Q99519
基因名：

NEU1
別名：

Acetylneuraminyl hydrolase antibody; exo-alpha-sialidase antibody; G9 sialidase antibody; Lysosomal sialidase antibody; N acetyl alpha neuraminidase 1 antibody; N-acetyl-alpha-neuraminidase 1 antibody; NANH antibody; NEU antibody; NEU1 antibody; NEUR1_HUMAN antibody; Neuraminidase 1 antibody; Neuraminidase antibody; SIAL1 antibody; sialidase 1 (lysosomal sialidase) antibody; Sialidase 1 antibody; Sialidase; lysosomal antibody; Sialidase-1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Sialidase-1 protein (201-415AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，NEU1 Antibody (CSB-PA17249A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于NEU1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA17249B0Rb	NEU1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA17249C0Rb	NEU1 Antibody, FITC conjugated
Biotin	CSB-PA17249D0Rb	NEU1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
基因功能參考文獻(xiàn)：
1. in monocytes/macrophages, NEU1 is interconnected in a positive feedback loop with lipopolysaccharides and IL-1beta as enhancers of inflammation, and may therefore promote atherosclerosis and plaque instability PMID: 29371126
2. Patients with minimally invasive and lepidic adenocarcinomas were categorized as low-risk group with high EGFR mutation rate; Patients with micro-papillary and solid adenocarcinomas were categorized as high-risk with lower EGFR mutation rate PMID: 29496311
3. Transmembrane topology and dimerization ability of NEU1 have been reported. PMID: 27917893
4. this work identified NEU1 as a novel biomarker for both diagnosis and prognosis in hepatocellular carcinoma PMID: 27602751
5. Our combined data indicate that as HPMECs achieve confluence and CD31 ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31, permitting NEU1-mediated desialylation of CD31. PMID: 28343945
6. TLR4 protein PMID: 29375116
7. neuraminidase-1 (Neu1) in complex with matrix metalloproteinase-9 and G protein-coupled receptor tethered to RTKs and TLRs is identified as a major target in multistage tumorigenesis [review] PMID: 27029067
8. EGFR protein, human is predictive of adjuvant chemo response. Also, It is a prognostic factor. PMID: 28862415
9. Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS). PMID: 28186588
10. Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis. PMID: 26993524
11. initial treatment with an EGFR-TKI is a reasonable option for patients presenting with EGFR mutation-positive NSCLC and a CM. PMID: 28237165
12. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
13. NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment PMID: 26463994
14. How the point mutations of the neuraminidase sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations PMID: 26455375
15. Our study shows that the 340-cavity is not an occasional or atypical domain in NA subtypes, and it has potential to function as a new hotspot for influenza drug binding. PMID: 26768362
16. Basal Neu-1 catalytic activity is strongly increased in aged cells. PMID: 26086247
17. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia. PMID: 26185093
18. Muc1 clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia PMID: 25925251
19. This study analyzed patient cells with GM1 gangliosidosis and sialidosis. A novel mutation p.R347Q is identified in NEU1 gene. PMID: 25600812
20. The lymphocyte levels of NEU1 and ST6GAL1 mRNA expression are significantly increased in erythremia. PMID: 25566667
21. Insulin-induced phosphorylation of the insulin receptor is dependent on Neu1 sialidase activity. PMID: 24583283
22. Sialidosis should be suspected and the NEU1 gene analyzed in patients with isolated action myoclonus presenting in adulthood in the absence of other typical clinical and laboratory findings. PMID: 24808020
23. catalytically active NEU1 inhibits in vitro angiogenesis through desialylation of its substrate, CD31 PMID: 24550400
24. Three novel mutations in the NEU1 gene in two Indian patients of sialidosis, one with the type I form and the other with the infantile type II form are reported here. PMID: 23391804
25. NEU1 gene missense mutation was found in a patient diagnosed with type I sialoidosis. PMID: 23291686
26. Weak anchorage of NEU1 and NEU3 to the plasma membrane and their loss during erythrocyte life could be a tool to preserve the cellular sialic acid content to avoid early aging of erythrocyte and processes of cell aggregation in the capillaries. PMID: 22903576
27. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding. PMID: 22989879
28. Data show that NEU1 was immunolocalized to both the plasma membrane and the perinuclear region, and NEU3 was detected both in the cytosol and nucleus. PMID: 22403397
29. Neuraminidase 1 as a modulator of cell receptors. (Review) PMID: 21928149
30. a novel Neu1 and MMP9 cross-talk in alliance with TLR4 on the cell surface that is essential for ligand activation of TLRs and subsequent cellular signaling. PMID: 21873432
31. colocalized with CD18 in PMNs; could be a physiologic source of the enzymatic activity that removes sialyl residues on beta2 integrin and ICAM-1, resulting in their enhanced interaction PMID: 21551251
32. Data show that Neu-1 siRNA blocks the process of GM(3)/LacCer conversion. PMID: 21103358
33. Summary of NEU1 mutations found in sialidosis patients. PMID: 14517945
34. type II sialidosis associated mutations in NEU1 affect lysosomal sialidase activity. PMID: 14695530
35. Data show that the differentiation of monocytes into macrophages is associated with regulation of the expression of at least three distinct cellular sialidases, Neu1, 3, and 4, with specific up-regulation of the enzyme activity of only Neu1. PMID: 15885103
36. Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface to facilitate elastic fiber assembly PMID: 16314420
37. effects of GLB1, PPCA and NEU1 gene mutations on elastogenesis in skin fibroblasts PMID: 16538002
38. upregulation of the Neu1 expression is important for the primary function of macrophages and there is a link between Neu1 and the cellular immune response PMID: 16835219
39. Activation of lymphocytes resulted in a ninefold increase in Neu1-specific activity after growth of cells in culture for 5 days.Cell surface Neu1 was found tightly associated with a subunit of protective protein/cathepsin A (PPCA). PMID: 17028199
40. Female cervical mucus contains an endogenous menstrual cycle-related sialidase that could be involved in modifying the rheologic properties of mucus to favor sperm progression at fertilization. PMID: 17562335
41. NEU1 is a negative regulator of lysosomal exocytosis. PMID: 18606142
42. related to malignancy and may be potential targets for cancer diagnosis and therapy PMID: 18651674
43. Neuraminidase caused the desialylation of both PDGF and IGF-1 receptors and diminished the intracellular signals induced by the mitogenic ligands PDGF-BB and IGF-2. PMID: 18772331
44. results suggest that NEU1 is important in regulation of integrin beta4-mediated signaling, leading to suppression of metastasis PMID: 19151752
45. findings show homozygous mutations of NEU1 544A-->G (Ser182Gly substitution) play a major role of the genotype and phenotype of Sialidosis type 1 PMID: 19473359
46. The genetic characterization of the two patients showed one known [c. 679G > A (p.G227R)] NEU1 missense mutation (detected in P2), and the new c.807 + 1G > A splicing defect PMID: 19568825
47. Results describe the hydrodynamic properties of PPCA, NEU1, and a complex of the two proteins and identified multiple binding sites on both proteins. PMID: 19666471
48. occurrence of Neu3 in the inner membrane and Neu1 in the outer membrane of the nuclear envelope PMID: 19686243
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相關(guān)疾?。?/div>
Sialidosis (SIALIDOSIS)
亞細(xì)胞定位：

Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Lysosome. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
蛋白家族：

Glycosyl hydrolase 33 family
組織特異性：

Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.
數(shù)據(jù)庫鏈接：

HGNC: 7758

OMIM: 256550

KEGG: hsa:4758

STRING: 9606.ENSP00000364782

UniGene: Hs.520037

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