MYL9 (US10513561B2 Biosimilar) Recombinant Monoclonal Antibody
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貨號：CSB-RA015318MB1HU
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規格：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Myosin regulatory light polypeptide 9；20 kDa myosin light chain；LC20；MLC-2C；Myosin RLC；Myosin regulatory light chain 2, smooth muscle isoform；Myosin regulatory light chain 9；Myosin regulatory light chain MRLC1, MYL9, MLC2 MRLC1 MYRL2
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反應種屬：Human
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免疫原：Recombinant Human MYL9 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.34 -
產品提供形式：Liquid
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應用說明：Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：In stock
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用途：It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
產品評價
相關產品
靶點詳情
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功能：Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
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基因功能參考文獻：
- MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
- At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
- These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
- the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
- Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
- Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
- surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
- The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
- Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
- use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058
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亞細胞定位：Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
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組織特異性：Smooth muscle tissues and in some, but not all, nonmuscle cells.
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數據庫鏈接：
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