IL13RA1 (eblasakimab Biosimilar) Recombinant Monoclonal Antibody
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貨號：CSB-RA011591MB1HU
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規格：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：bB128O4.2.1；interleukin 13 receptor; alpha 1 antibody; Cancer/testis antigen 19 antibody; CD213a1 antibody; CD213A1 Antigen antibody; CT 19 antibody; CT19 antibody; I13R1_HUMAN antibody; IL 13 receptor subunit alpha 1 antibody; IL 13R alpha 1 antibody; IL 13R subunit alpha 1 antibody; IL 13Ra antibody; IL 13RA1 antibody; IL-13 receptor subunit alpha-1 antibody; IL-13R subunit alpha-1 antibody; IL-13R-alpha-1 antibody; IL-13RA1 antibody; IL13 receptor alpha 1 chain antibody; IL13R antibody; IL13RA antibody; Il13ra1 antibody; Interleukin 13 receptor alpha 1 antibody; Interleukin 13 receptor alpha 1 chain antibody; interleukin 13 receptor subunit alpha 1 antibody; Interleukin-13 receptor subunit alpha-1 antibody; NR 4 antibody; NR4 antibody
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反應種屬：Human
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免疫原：Recombinant Human IL13RA1 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.121 -
產品提供形式：Liquid
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應用說明：Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：In stock
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用途：It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
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靶點詳情
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功能：Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
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基因功能參考文獻：
- High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
- in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
- sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
- IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
- required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
- Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
- miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
- MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
- In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
- These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
- The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
- IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
- Mutation and functional analysis in human malignant glioma cells PMID: 11939409
- IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
- Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
- Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
- Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
- IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
- the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
- concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Type I cytokine receptor family, Type 5 subfamily
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組織特異性：Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
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