CDH11 (RG6125 Biosimilar) Recombinant Monoclonal Antibody

說明書

貨號：

CSB-RA005036MB1HU
規格：
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P55287
基因名：

CDH11
別名：

CAD11 antibody; CAD11_HUMAN antibody; Cadherin 11 antibody; Cadherin 11 type 2 antibody; Cadherin 11 type 2 OB cadherin；osteoblast antibody; Cadherin-11 antibody; Cdh11 antibody; CDHOB antibody; OB antibody; OB-cadherin antibody; OBcadherin antibody; OSF-4 antibody; OSF4 antibody; Osteoblast cadherin antibody
反應種屬：

Human
免疫原：

Recombinant Human CDH11 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.136
產品提供形式：

Liquid
應用說明：

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

In stock
用途：

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

功能：

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
基因功能參考文獻：
1. Elevated levels of PLAUR, a validated target gene, and CDH11 were confirmed in gastric tumors with low expression of miR-335. The 3'UTR of CDH11 was identified to be directly targeted by miR-335. PMID: 29075357
2. This study reveals loss-of-function mutations in CDH11 as a probable cause of Elsahy-Waters syndrome phenotype. PMID: 28988429
3. the observed CDH11 expression in active MM patients' peripheral blood was carried by circulating plasma cell clone(s), outgoing from an osteoblastic niche, conferring the disease transformation into symptomatic MM or its relapse. PMID: 27118219
4. data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors PMID: 29190819
5. Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11. PMID: 28292214
6. engagement of CDH11 through homophilic interactions, led to swift activation of the TGF-beta and ROCK pathways as evidenced by phosphorylation of downstream effectors. PMID: 27311482
7. Cad-11 expression was significantly increased in pancreatic stellate cells and pancreatic cancer cells. PMID: 27855278
8. Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells, while downregulation of miR-27b suppressed the proliferation and invasion of HeLa cells PMID: 26706910
9. observations suggest that clathrin-mediated internalization of Cad11 regulates surface trafficking of Cad11 and that dynamic turnover of Cad11 regulates the migratory function of Cad11 in prostate cancer cells. PMID: 26519476
10. that U87-p75(NTR) cells express higher levels of Cdh-11 protein and that siRNA-mediated knockdown of Cdh-11 resulted in a significant decrease in p75(NTR)-mediated glioblastoma cell migration PMID: 26476273
11. Invasive cancer cells had increased expression of mesenchymal markers cadherin 2 and 11 that localized with stromal cell cadherin 11, suggesting that these molecules are involved in stromal cell engraftment. PMID: 26046821
12. Data suggest methylation status of gene promoters for CDH11 (cadherin 11) and BASP1 (brain abundant membrane attached signal protein 1) in tumor, skin, and metastatic tumor tissue may serve as prognostic biomarkers in patients with advanced melanoma. PMID: 25919928
13. Cadherin-11 may be hyper-expressed in the peripheral blood of diffuse systemic scleroderma patients. PMID: 26121083
14. Our results demonstrate that parathyroid hormone stimulates hematopoiesis through promoting the upregulation of CDH11 expression in bone marrow mesenchymal stromal cells PMID: 24648356
15. High Cad-11 expression is associated with bone metastases of Ewing sarcoma. PMID: 26092671
16. evidence for the involvement of CDH11 in Autism Spectrum Disorder which is consistent with the association of other cadherins with Autism Spectrum Disorder and neuropsychiatric diseases PMID: 24839052
17. Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma. PMID: 24940649
18. This study evaluated the expression of CAD11 in the peripheral blood of rheumatoid arthritis patients and normal controls. PMID: 25173800
19. High Cadherin-11 expression is associated with breast cancer. PMID: 24681547
20. Data indicate that knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFbeta-stimulated migration. PMID: 23951053
21. These data demonstrate that Cad-11 is a mediator of dermal fibrosis and TGFbeta production and suggest that Cad-11 may be a therapeutic target in systemic sclerosis. PMID: 24757152
22. Data indicate that the interaction of mesenchymal stem cells (MSC) with fibroblast-like synoviocytes (FLS) via cadherin-11 may contribute to angiogenesis and chronic synovitis by enhancing the secretion of placental growth factor (PlGF). PMID: 24574497
23. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
24. Results indicate the necessity of cadherin-11 for dystrophic calcific nodule formation, which proceeds through an Erk1/2-dependent pathway. PMID: 23162011
25. The study of CDH11 5'-CpG island hypermethylation in primary tumours and lymph node metastases of cancer patients showed this epigenetic alteration to be significantly confined to the disseminated cells. PMID: 22374749
26. Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas. PMID: 22139084
27. These results show the functional significance of cadherin-11 expression in glioblastoma multiforme. PMID: 22267545
28. CDH11 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. PMID: 21722156
29. CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients. PMID: 21990376
30. increased expression in patients with rheumatoid arthritis PMID: 21798287
31. cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA. PMID: 21536877
32. suppression of MUC1 by miR-145 causes a reduction of beta-catenin as well as the oncogenic cadherin 11 PMID: 19996288
33. The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation PMID: 11775026
34. CADH11 was evaluated as a biomarker at the protein level and was found to have increased expression in xenograft tumors after S11248 treatment. PMID: 14985702
35. A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma. PMID: 15383628
36. primary aneurysmal bone cysts are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements PMID: 15509545
37. Review. Cadherin-11 expression confers upon cells a fundamental change in cellular behavior. Its expression on fibroblast-like synoviocytes may determine their behavior & differentiation. PMID: 15743489
38. Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue. PMID: 16651616
39. Cadherin-11 is involved in the intercellular physical coupling of detrusor smooth muscle bladder cells and also of myofibroblasts. PMID: 17292535
40. Overexpression of osteoblast cadherin is associated with breast cancer cell metastatic potential PMID: 18193170
41. The results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma. PMID: 18359978
42. cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases. PMID: 18575746
43. These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone. PMID: 18708358
44. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation PMID: 18821672
45. Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas. PMID: 19133007
46. Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR PMID: 19274078
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相關疾病：

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
組織特異性：

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
數據庫鏈接：

HGNC: 1750

OMIM: 600023

KEGG: hsa:1009

STRING: 9606.ENSP00000268603

UniGene: Hs.116471

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