Recombinant Xenopus laevis 5-hydroxytryptamine receptor 1A (htr1a)

in vitro E.coli expression system

中文名稱：

有爪蟾蜍htr1a重組蛋白
貨號(hào)：

CSB-CF836541XBE
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

htr1a
Uniprot No.：

Q98998
別名：

htr1a; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; x5-HT1A; Serotonin receptor 1A
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-408
氨基酸序列

MDASNNTTSWNILQRGRMGPSWRRCPVSYQIIASLFLGRSFSAGIFGNACVIAAIALERS LQNVANYLIGSLAVTDLMVSVLVLPMAAQNQVLNKWTLGQVTCDIFISLDVLCCTSSILH LCAIALDRYWAITDPIDYVNKRTPRRAAVLISITWIVGFSISIPPMLGWRTPEDRSDPNA CRISEDPGYTIYSTFGAFYIPLILMLVLYGKIFKAARFRIRKTVKKAEKKKVADTCLSVS QQSPKEKQRGAQQELEEVGGAQAQRCVNGAIRHGEEGAVLEIIEVHHYVNSKCHLHCKPV PPPEQLPPALKNDRATEAKRKVALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCET CHMPHLLFDIITWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCKFCRQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior. Activation of the receptor may play a role in the exit from G0 phase and in promoting DNA synthesis.
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
蛋白家族：

G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily, HTR1A sub-subfamily
組織特異性：

First expressed in the rostral part of the brain stem at stage 22. At later stages of development, expression is localized to serotonergic neurons. The expression pattern changes in the tadpole of stage 41 where, in addition to serotonergic neurons, expre
數(shù)據(jù)庫鏈接：

KEGG: xla:378605

UniGene: Xl.1104